Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
204-673-3
CAS no.:
124-04-9
Index number:
607-144-00-9
Molecular formula:
C6H10O4
SMILES:
OC(=O)CCCCC(O)=O
InChI:
InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
30
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes serious eye damage.

Breakdown of all 5495 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Eye Dam. 1 H318
Not Classified
Aquatic Chronic 3 H412
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (0.81% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 119 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals and washing & cleaning products.

This substance is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: laboratory work, transfer of chemicals, transfer of substance into small containers and in materials as fuel sources, with limited exposure to unburned product to be expected.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: pH regulators and water treatment products, leather treatment products and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and as processing aid.

This substance is used in the following products: pH regulators and water treatment products, polymers and leather treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals, plastic products and textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as processing aid, for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and formulation of mixtures. Other release to the environment of this substance is likely to occur from: outdoor use as reactive substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • A.Schulman GmbH, Hüttenstrasse, 211 D 50170 Kerpen Germany
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Allnex Belgium NV/SA, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium NV/SA OR2, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium OR3, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Italy S.R.L., Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy
  • ALSACHIMIE, Route départementale 52 68490 Chalampé France
  • Amik Italia, VIA MECENATE 84B 20138 MILANO Italy Italy
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • ARKEMA PHOTOCURES, 420 rue d'Estienne d'Orves 92700 Colombes France
  • Ascend Performance Materials srpl/bvba, Watson & Crick Hill Park 11, rue Granbonpré - Bâtiment H B-1348 Louvain-la-Neuve Walloon Brabant Belgium
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • B-Lands Consulting (811715-1), 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • BASF Polyurethanes GmbH, Elastogranstr. 60 49448 Lemförde Niedersachsen Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCS Only Representative Services Ltd 019, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • BOSTIK S.A., 420, rue d’Estienne d’Orves 92705 Colombes Cedex France France
  • C.S.B. GmbH, Düsseldorfer Str. 113 47809 Krefeld Germany
  • Cardolite Specialty Chemicals Europe NV (OR for IXE), Wijmenstraat 21 K bus 2 B-9030 Mariakerke (Gent) Belgium
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Unit 1 Ardee Business Park, Hale Street Co. Louth Ardee Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemservice S.A. (B1KR), 13, Fausermillen 6689 Mertert Luxembourg
  • Chemservice S.A. (TZ6C), 13, Fausermillen 6689 Mertert Luxembourg
  • COVANCE CLINICAL DEVELOPMENT SA 017, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Covance Clinical Development SA 155, Parque Empresarial Las Tablas, Edifico 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR CN_001554, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001257, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Croda EU B.V. (OR1), Buurtje 1 2802 BE Gouda Netherlands
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • CS Regulatory IRL Ltd 1L-13, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Daedong System Poland, ul. Mała Łąka 28/32 43-400 Cieszyn Poland
  • DOMO Engineering Plastics Poland Sp. z o.o., ul. Walczaka 25 66-407 Gorzow Wielkopolski Poland
  • DOMO Polymer Solutions Spain SL, AVINGUDA DE L'ESTACIO, 74 17300 BLANES Spain
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DSM Coating Resins B.V., Ceintuurbaan 5 8022 AW Zwolle Netherlands
  • DSM Engineering Materials B.V., Urmonderbaan 22 6167RD Geleen Netherlands
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • ERM_GmbH_OR_27_KEGHK, Siemenstrasse 9 63263 Neu Isenburg Hessen Germany
  • ETO Magnetic GmbH, Hardtring 8 78333 Stockach Germany
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Fista, 't Ven 35 5091BN Middelbeers Netherlands
  • Genencor International B.V. - OR-US, Willem Einthovenstraat 4 2342 BH Oegstgeest Netherlands
  • Hallstar Italia Srl con socio unico , Piazza Meda, 3 20121 Milano Lombardia Italy
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd, Rubicon Building C.I.T. Campus T12 Y275 Bishopstown Cork Ireland
  • Huntsman (Europe) BV - OR8, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • INEOS Composites Hispania S.L. (0341), Partida Povet, 37 ES-12580 Benicarlo Castellón de la Plana Spain
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • INV Nylon Chemicals Netherlands B.V., Parmentierweg 4, 5657 EH Eindhoven Netherlands
  • INV Nylon Chemicals Netherlands B.V. OR CHN, Parmentierweg 4 5657 EH Eindhoven Netherlands
  • INV Nylon Chemicals Netherlands B.V. OR US, Parmentierweg 4 5657 EH Eindhoven Netherlands
  • Kao Chemicals Europe, S.L. (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Knoell NL_OR_083, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • LANXESS Sales Netherlands B.V., Groot Egtenrayseweg 23 5928 PA Venlo Netherlands
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 19, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Marubeni International (Europe) GmbH, Benrather Str. 18-20 40213 Düsseldorf Germany
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • MICHELMAN INTERNATIONAL BELGIUM SRL, Zoning Industriel B-6790 Aubange Belgium
  • MITSUBISHI GAS CHEMICAL EUROPE GMBH, Immermannstr. 13 40210 Duesseldorf Germany
  • MITSUBISHI GAS CHEMICAL EUROPE GMBH, Immermannstr.13 40210 Duesseldorf Germany
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Novamont, via Fauser 8 28100 Novara Italy
  • Novozymes A/S, Krogshoejvej 36 2880 Bagsvaerd Denmark
  • Only representative (No publishable name), null
  • PCC Trade & Services GmbH, Moerser Strasse 149 47198 Duisburg Germany
  • PetroChina International (Netherlands) Company B.V, Vasteland 78 HNK Rotterdam Scheepvaartkwartier 3011BN Rotterdam Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • Radici Chimica Deutschland GmbH, Dr. Bergius Strasse 6 D 06729 Elsteraue OT Troeglitz Germany
  • Radici Chimica S.p.A., via Fauser 50 28100 Novara Italy
  • Ramboll Belgium BVBA (TSE), Meersbloem-Melden 46 9700 Oudenaarde Belgium
  • Reach Only Representative (Ireland) Ltd (shakesp), VPR House Main Street F12 FC64 Swinford County Mayo Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • RHODIA OPERATIONS - 1, 52 rue de la Haie Coq 93300 Aubervilliers France
  • Rohm and Haas Italia Srl, Via Trieste 25 22076 Mozzate Como Italy
  • SG PERFORMANCE PLASTICS FRANCE, LA MOTHE-AUX-AULNAIES 89120 CHARNY France
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Pesetastraat 62 2991 XT Barendrecht Netherlands
  • Solvay Specialty Polymers Italy S.p.A., Viale Lombardia 20 20021 BOLLATE Italy
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • STEPAN POLSKA, Urazka Street PL 56-120 Brzeg Dolny Poland
  • Teknor Apex BV, Mijnweg 1 Mijnweg 1, (P.O.Box 601, 6160 AP) 6167AC Geleen Please select Netherlands
  • TÜV SÜD Iberia, S.A.U., Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany
  • VAMP - TECH S.p.A., Via delle Industrie 10/12 20874 Busnago Italy
  • YF International b.v., Burg. van Dorth tot Medlerstraat 34 6921 AZ Duiven Netherlands
  • ZANGAS Hoch-und Tiefbau GmbH, Schwindgasse 5/1/4 1040 Vienna Vienna Austria
  • [Confidential], [Confidential]
  • HH Compliance Ltd., The Rubicon Building, CIT Campus Bishopstown N/A Cork Ireland
  • REACH COMPLIANCE SERVICES LIMITED, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Showa Denko Europe GmbH (SDK), Werner-von-Siemens-Straße 18 86405 Meitingen Germany
  • W. L. Gore & Associates (UK) Ltd., Kirkton South Road Kirkton Campus EH54 7BT Livingston United Kingdom
  • ZANGAS Hoch-und Tiefbau GmbH, Schwindgasse 5/1/4 1040 Vienna Vienna Austria

Substance names and other identifiers

1,4-Butanedicarboxylic acid
Other
1,6-Hexanedioic acid
Other
Acide adipique
Other
Acifloctin
Other
Acinetten
Other
Adilactetten
Other
Adipate
Other
Adipic acid
EC Inventory, C&L Inventory, REACH pre-registration, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances
Adipic acid
C&L Inventory, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances
Adipinic acid
Other
Adipinsaure
Other
Kyselina adipova
Other
Molten adipic acid
Other
acid adipic (ro)
C&L Inventory
acide adipique (fr)
C&L Inventory
acido adipico (it)
C&L Inventory
Adipiinhape (et)
C&L Inventory
Adipiinihappo (fi)
C&L Inventory
adipinezuur (nl)
C&L Inventory
adipinsav (hu)
C&L Inventory
adipinska kiselina (hr)
C&L Inventory
adipinska kislina (sl)
C&L Inventory
adipinsyra (sv)
C&L Inventory
adipinsyre (da)
C&L Inventory
adipinsyre (no)
C&L Inventory
Adipinsäure (de)
C&L Inventory
adipo rūgštis (lt)
C&L Inventory
adipová kyselina (cs)
C&L Inventory
adipīnskābe (lv)
C&L Inventory
hexandikarboxylsyra (sv)
C&L Inventory
kwas adypinowy (pl)
C&L Inventory
kwas butano-1,4-dikarboksylowy (pl)
C&L Inventory
kyselina adipová (sk)
C&L Inventory
ácido adípico (es)
C&L Inventory
ácido adípico (pt)
C&L Inventory
αδιπικό οξύ (el)
C&L Inventory
адипинова киселина (bg)
C&L Inventory
Hexanedioic acid
Other
1, 4-butanedicarboxylic acid
C&L Inventory, Registration dossier
1,4-Butanedicarboxylic acid
Registration dossier
1,4-buthanediacetic acid
C&L Inventory
1,6-HEXANEDIOIC ACID
C&L Inventory, Registration dossier
ADIPIC ACID
C&L Inventory, Registration dossier
ADIPIC ACID
C&L Inventory, Registration dossier
Adipic acid ,CAS N°124-04-9, Radici Chimica S.p.A.
Registration dossier
Adipic acid, CAS N° 124-04-9 Radici Chimica Deutschland GmbH
Registration dossier
Adipinsäure
C&L Inventory
adipová kyselina
C&L Inventory
Hexamethylenediamine-adipate
C&L Inventory
hexan-1,6-dioic acid
C&L Inventory
hexane-1,6-dioic acid
C&L Inventory
Hexanedioic Acid
C&L Inventory, Registration dossier, Other
Hexanedioic acid / Adipic acid
Registration dossier
1,4-BUTANEDICARBOXYLIC ACID
Registration dossier
1,6-HEXANEDIOIC ACID
Registration dossier
Acido adipico
C&L Inventory, Registration dossier
Acifloctin
Registration dossier
Acinetten
Registration dossier
Adilactetten
Registration dossier
ADIPIC ACID
C&L Inventory, Registration dossier
Adipic acid (8CI)
Registration dossier
adipin saure
Registration dossier
ADIPINIC ACID
Registration dossier
ADIPINSAEURE
Registration dossier
ADIPINSAEURE MOL 146.1
C&L Inventory
Automotive coatings
Registration dossier
CRISVON MP-812NB
Registration dossier
CRISVON SPM-82B
Registration dossier
DELION 4000-90
Registration dossier
DELION F-2232-R
Registration dossier
DELION MD-1-A
Registration dossier
DYNAGRAND IS-073-D-U
Registration dossier
GS Pla
Registration dossier
HEXANEDIOIC ACID
Registration dossier
Hexanedioic acid (9CI)
Registration dossier
HYDRAN HW-311
Registration dossier
LEONA
Registration dossier
MP6 Nylon
Registration dossier
MX Nylon
Registration dossier
Polyamide MP6
Registration dossier
Polyamide MXD6
Registration dossier
POLYLITE OD-X-2541
Registration dossier
POLYLITE OD-X-688
Registration dossier
Radichem adipic acid
Registration dossier
Radiplus
Registration dossier
Reny
Registration dossier
SA-2019MP
Registration dossier
SS-1037MP
Registration dossier
Superflex 820 - 3H
Registration dossier
TECHNYL 1239 FL BLACK, TECHNYL 2720ST BLACK, KOPLA KDK1040BK, KOPLA KDP 1000R, KOPLA KDG1030, KOPLA KDG1030 BK900RD, KOPA KN333G30BL, KOPA KN333HRBL
Registration dossier
This substance is a monomer in an imported polymer, therefore no trade names are available and/or relevant.
Registration dossier
VONDIC 1980NE
Registration dossier
VONDIC 518NEF
Registration dossier
WATERSOL WAW-620
Registration dossier
XYRON
Registration dossier
Adipic acid
REACH pre-registration
Hexanedioic acid
REACH pre-registration
1186514-28-2
CAS number
Other
1186514-28-2
Deleted CAS number
Other
124-04-9
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances
2023788-68-1
CAS number
Other
2023788-68-1
Deleted CAS number
Other
607-144-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Solid: crystalline (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: crystalline (100%)
Colour
white (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 1 study processed
R Melting / freezing point
150.85 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
150.85 °C

Boiling point

Study results
  • 9 studies submitted
  • 1 study processed
R Boiling point
337.5 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other 1 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
337.5 °C

Density

Study results
  • 8 studies submitted
  • 1 study processed
R Relative density
1.36 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.36

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
9.7 Pa @ 18.5 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
9.7 Pa @ 18.5 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
0.093 - 0.23 @ 25 °C and pH 3.3 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.09 @ 25 °C

Water solubility

Study results
  • 8 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
23 g/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
23 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 5 studies submitted
  • 1 study processed
R Flash point
196 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
196 °C

Auto flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 5 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
4.34 - 5.44 @ 18 - 25 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
69.6 h
Degradation rate constant with OH radicals
5.787 cm³ molecule-1 s-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 15 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (50%), Inherently biodegradable (50%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 11
Weight of evidence
Other 1 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
3.16 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
1.61

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0.062 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 2.09 % [1]
R Water 97.89 % [1]
R Soil 0.01 % [1]
R Sediment 0.01 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 126 µg/L (1)
Intermittent releases (freshwater) 460 µg/L (1)
Marine water 12.6 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) 474 µg/kg sediment dw (1)
Sediment (marine water) 47.4 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 20.8 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 9 studies submitted
  • 1 study processed
P/RResults
LC0 (4 days) 1 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 3 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (48 h) 46 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 6.3 mg/L [1]
EC50 (21 days) 17.6 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 64.5 mg/L [1]
NOEC (72 h) 40.6 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
64.5 mg/L
EC10 or NOEC for freshwater algae
40.6 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 100 mg/L [1]
NOEC (3 h) 100 mg/L [1]
EC10 (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 74.1 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 21 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 13 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 7
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 11 studies submitted
  • 1 study processed
P/RResults
LD50 5 560 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 7
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
LC0 (4 h) 7.7 mg/L air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD0 7 940 mL/kg bw (rabbit) [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 6
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 15 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 750 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 11
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other 1 1
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 750 mg/kg bw/day (chronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant