Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Bis(2-ethylhexyl) phthalate
  • IUPAC name: 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
  • Other names
EC / List no.:
204-211-0
CAS no.:
117-81-7
Index number:
607-317-00-9
Molecular formula:
C24H38O4
SMILES:
CCCCC(CC)COC(=O)C1=C(C=CC=C1)C(=O)OCC(CC)CCCC
InChI:
InChI=1/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
20
Of which contain:
4 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may damage fertility and may damage the unborn child.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child and is very toxic to aquatic life.

Breakdown of all 799 C&L notifications submitted to ECHA

Repr. 1B H360FD Harmonised Classification
Aquatic Chronic 3 H412
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
Eye Irrit. 2 H319
Repr. 1A H360
Aquatic Chronic 2 H411
Carc. 2 H351
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 17 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Substance of very high concern requiring authorisation before it is used (Annex XIV of REACH).
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), rubber (e.g. tyres, shoes, toys) and fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys).

This substance is used in the following products: polymers and laboratory chemicals.

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: plastic products and chemicals.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, laboratory work, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation in materials, formulation of mixtures, in the production of articles and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, calendering operations, transfer of chemicals, the low energy manipulation of substances bound in materials or articles, roller or brushing applications, treatment of articles by dipping and pouring, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; obtain special instructions before use; use personal protective equipment as required..

Response statements

In case of incident: If exposed or concerned: get medical advice/attention.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Baxter SA, Boulevard René Branquart 80 7860 Lessines Belgium
  • Boryszew S.A. Oddzial Boryszew ERG w Sochaczewie, 15-go Sierpnia 106 96-500 Sochaczew Mazowsze Poland
  • Covidien Group SARL, Bd. Prince Henri 3b, 4th Floor L- 1724 Luxembourg Luxembourg
  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • Knoell NL-OR-S20, Agro Business Park 75 6708 PV Wageningen Netherlands
  • LG Chem Europe GmbH, Lyoner str 15, Atricom C6, D-60528 Frankfurt am Main Germany
  • Liquichem Handelsgesellschaft mbH, Beselerstraße 2a 22607 Hamburg Germany
  • momaja s.r.o., Karolinská 650/1 186 00 Prague 8 Czech Republic
  • Murata Elektronik GmbH, Holbeinstr. 23 90441 Nürnberg Germany
  • POLYNT S.p.A., via Enrico Fermi, 51 24020 Scanzorosciate Italy
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • VEYANCE TECHNOLOGIES CZECH s.r.o., Na Rovince 873 72000 Ostrava Czech Republic
  • [Confidential], [Confidential]
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. poczt. 163 ul. Mostowa 30A 47-220 Kędzierzyn-Kożle Poland
  • Mexichem UK Limited_OR3, The Heath Business and Technical Park WA7 4QX Runcorn Cheshire United Kingdom
  • OLTCHIM SA, Uzinei 1 240050 Ramnicu Valcea Valcea Romania
  • Perstorp Oxo AB, Sanden Ödsmål 444 84 Stenungsund Sweden
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 Box 5 B-1040 Brussels Belgium
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman,6 Box 5 B-1040 Brussels Belgium
  • SG PERFORMANCE PLASTICS FRANCE, LA MOTHE-AUX-AULNAIES 89120 CHARNY France

Other names

  • -
  • 1,2-Benzenedicarboxylic acid bis (2-ethylhexyl) ester
  • 1,2-BENZENEDICARBOXYLIC ACID, [BIS(2-ETHYLHEXYL)] ESTER
  • 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
  • 2-ethylhexyl
  • Bis (2-Ethylhexyl) Phthalate (DEHP)
  • bis (2ethylhexyl)benzene-1,2-dicarboxyacid
  • bis(2-ethylhexyl) benzene-1,2-dicarboxylate
  • bis(2-ethylhexyl) phtalate
  • Bis(2-ethylhexyl) Phthalate
  • bis(2-ethylhexyl) phthalate; di-(2-ethylhexyl) phthalate; DEHP
  • Bis(2-ethylhexyl)-phthalat
  • Bis(2-ethylhexyl)benzene-1,2-dicarboxylate
  • bis(2-ethylhexyl)phtalate
  • Bis(2-ethylhexyl)phthalat
  • BIS(2-ETHYLHEXYL)PHTHALATE
  • Bis(2-ethylhexyl)phthalate (BEHP)
  • DEHP
  • Di(2-ethylhexyl) phthalate
  • Di-(2-ethylhexyl) phthalate
  • Di-2-ethyl Hexyl phthalate
  • Di-2-ethylhexyl phthalate
  • Diethylhexylphthalate
  • Diethylhexyphthalate
  • DIOCTYL PHTHALATE
  • UPV18
  • Bis (2-ethylhexyl) phthalate (DEHP)
  • Bis (2-ethylhexyl)phthalate (DEHP)
  • Bis(2-ethylhexyl) phthalate
  • Bis(2-ethylhexyl) phthalate (DEHP)
  • DEHP
  • di-(2-ethylhexyl) phthalate
  • 1,2-Benzenedicarboxylic acid, bis(ethylhexyl) ester
  • Bis(2-ethylhexyl) o-phthalate
  • bis(2-ethylhexyl)-1,2-benzenedicarboxylate
  • bis(2-ethylhexyl)1,2-benzenedicarboxylate
  • DEHP
  • Di(ethylhexyl) phthalate
  • Dioctyl Phthalate
  • DIPLAST O/MG
  • DOP
  • Ergoplast FDO
  • LGFLEX DOP
  • OXOPLAST MEDICA
  • OXOPLAST O
  • OXOPLAST O 30
  • OXOPLAST O 40
  • OXOPLAST O K
  • Phtalate de bis(2-ethylhexyle)

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Other (100%) [3]
C Odour
Other (100%) [3]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 9 studies submitted
  • 6 studies processed
R Melting / freezing point
-55 - -50 °C [6]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-50 °C

Boiling point

Study results
  • 15 studies submitted
  • 3 studies processed
R Boiling point
333.82 - 374.15 °C @ 25 - 102.2 kPa [12]

Type of Study provided
Studies with data
Key study 3
Supporting study 9 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
373.85 °C

Density

Study results
  • 16 studies submitted
  • 7 studies processed
R Density
0.98 g/cm³ @ 20 °C [6]
R Relative density
0.982 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 9
Weight of evidence 3 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.98

Vapour pressure

Study results
  • 27 studies submitted
  • 12 studies processed
R Vapour pressure
0 - 0 Pa @ 20 - 25 °C [15]

Type of Study provided
Studies with data
Key study
Supporting study 12 3
Weight of evidence 6 3 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 31 studies submitted
  • 10 studies processed
R Log Pow
6.07 - 7.94 @ 25 - 30 °C and pH 5 - 8 [16]

Type of Study provided
Studies with data
Key study
Supporting study 3 12
Weight of evidence 10
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
7.5 @ 20 °C

Water solubility

Study results
  • 34 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
3 - 86 µg/L @ 20 - 25 °C and pH 6.24 - 7 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 4 6
Weight of evidence
Other 21
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
3 µg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 1 study processed
R Flash point
200 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
200 °C

Auto flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 3
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 7 studies submitted
  • 3 studies processed
R dynamic viscosity (in mPa s)
81 [2]
R kinematic viscosity (in mm²/s)
78.17 [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
78.17 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 9 studies submitted
  • 3 studies processed
R Dissipation half life (DT50)
24 h [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
24 h

Hydrolysis

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 57 studies submitted
  • 9 studies processed
C Interpretation of results
Readily biodegradable (67%), Under test conditions no biodegradation observed (33%) [9]

Type of Study provided
Studies with data
Key study 9
Supporting study 18
Weight of evidence
Other 6 24
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
50 days @ 12 °C
Half-life in sediment
10 months @ 12 °C

Biodegradation in soil

Study results
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 18
Weight of evidence
Other 3 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
10 months @ 12 °C

Bioaccumulation: aquatic / sediment

Study results
  • 39 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6
Supporting study 6 3
Weight of evidence
Other 9 15
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
614

Bioaccumulation: terrestrial

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 21 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 15
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 12
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (1)
Intermittent releases (freshwater) No hazard identified (1)
Marine water No hazard identified (1)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) 201 mg/L (3)
Sediment (freshwater) 100 mg/kg sediment dw (3)
Sediment (marine water) 20 mg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 13 mg/kg soil dw (3)
Hazard for Predators
Secondary poisoning 3.3 mg/kg food (3)

Short–term toxicity to fish

Study results
  • 24 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 160 - 670 µg/L [18]

Type of Study provided
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other 12 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 24 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 9
Weight of evidence
Other 6 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 33 studies submitted
  • 6 studies processed
P/RResults
EC50 (4 days) 180 µg/L [3]
EC50 (48 h) 3 µg/L [3]
LC50 (4 days) 370 µg/L [3]
EC10 (48 h) 3 µg/L [3]
NOEC (4 days) 180 - 370 µg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study 3 3
Weight of evidence 12
Other 12 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 24 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 158 µg/L [3]
LOEC (21 days) 811 µg/L [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 9
Weight of evidence
Other 12
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 12 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 3 µg/L [3]
EC10 (72 h) 3 µg/L [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 21 studies submitted
  • 3 studies processed
P/RResults
NOEC (3 h) 1 - 2.007 g/L [6]

Type of Study provided
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other 3 9
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC
2.007 g/L

Sediment toxicity

Study results
  • 24 studies submitted
  • 6 studies processed
P/RResults
NOEC (60 days) 780 - 1 380 mg/kg sediment dw [3]
NOEC (35 days) 1 000 mg/kg sediment dw [3]
NOEC (26 days) 1 000 mg/kg sediment dw [3]
LOEC (60 days) 1 560 - 2 760 mg/kg sediment dw [3]

Type of Study provided
Studies with data
Key study 6
Supporting study 12 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
1 000 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [3]
NOEC (7 days) 1 g/kg soil dw [3]
LC50 (14 days) 1 g/kg soil dw [3]
LC50 (7 days) 1 g/kg soil dw [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOEC (42 days) 1 g/kg soil dw [3]
NOEC (21 days) 5 g/kg soil dw [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 12 studies submitted
  • 3 studies processed
P/RResults
NOEC (18 days) 100 mg/kg soil dw [9]

Type of Study provided
Studies with data
Key study 3
Supporting study 6 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
130 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 12 studies submitted
  • 6 studies processed
P/RResults
NOEC (28 days) 300 - 1 000 mg/kg soil dw [9]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 6
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
300 mg/kg soil dw

Toxicity to birds

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 1 700 mg/kg diet [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1.7 g/kg food

Toxicity to mammals

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.6 mg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.4 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 130 µg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 720 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 36 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 261 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 57
Supporting study 156
Weight of evidence 15
Other 30 3
Data waiving
no waivers
Study data: dermal absorption
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 6
Supporting study 24
Weight of evidence
Other 3
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 5 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 42 studies submitted
  • 3 studies processed
P/RResults
LD0 20 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Not classified [3]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 9
Weight of evidence
Other 30
Data waiving
no waivers
inhalation
  • 9 studies submitted
  • 3 studies processed
M/CInterpretations of results
Not classified [3]

inhalation
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 6
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 20 mL/kg bw (rabbit) [3]
M/CInterpretations of results
Not classified [3]

dermal
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 9
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed Discriminating dose 20 000 mg/kg bw
Inhalation route:
Adverse effect observed Discriminating conc. 10 620 mg/m³
Dermal route:
Adverse effect observed LD50 19 800 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 25 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 18
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Study data: respiratory
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 222 studies submitted
  • 6 studies processed
P/RResults
NOAEL (mouse): 100 ppm [3]
NOAEL (primate): 2 500 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 9
Supporting study 87 3
Weight of evidence
Other 120 3
Data waiving
no waivers
Study data: inhalation
  • 12 studies submitted
  • 3 studies processed
P/RResults
NOAEC (rat): 50 mg/m³ air [3]

Study data: inhalation
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 6
Data waiving
no waivers
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 279 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 18
Supporting study 126
Weight of evidence
Other 135
Data waiving
no waivers
Study data: in vivo
  • 114 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 6
Supporting study 42
Weight of evidence
Other 66
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 84 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6
Supporting study 66
Weight of evidence
Other 12
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 123 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3
Supporting study 87
Weight of evidence
Other 33
Data waiving
no waivers
Study data: developmental
  • 183 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 18
Supporting study 48
Weight of evidence
Other 117
Data waiving
no waivers
Study data: other studies
  • 144 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 42
Weight of evidence
Other 102
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 46 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 1 000 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 57 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 21
Other 36
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant