Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-126-0
CAS no.:
78-59-1
Index number:
606-012-00-8
Molecular formula:
C9H14O
SMILES:
CC1=CC(=O)CC(C)(C)C1
InChI:
InChI=1S/C9H14O/c1-7-4-8(10)6-9(2,3)5-7/h4H,5-6H2,1-3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
8
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is harmful if swallowed, is harmful in contact with skin, causes serious eye irritation, is suspected of causing cancer and may cause respiratory irritation.

Breakdown of all 2246 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Acute Tox. 4 H312 Harmonised Classification
Carc. 2 H351 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
Acute Tox. 3 H331
STOT SE 3 H336
Skin Irrit. 2 H315
Eye Irrit. 2A H319
Acute Tox. 4 H332
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • ED
Under assessment as Endocrine Disrupting (ED list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 tonnes per annum.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: plant protection products.

This substance is used in the following areas: agriculture, forestry and fishing.

This substance is used in the following activities or processes at workplace: non-industrial spraying and transfer of chemicals.

Other release to the environment of this substance is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

This substance is used in the following products: coating products, plant protection products, washing & cleaning products and inks and toners.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: coating products, washing & cleaning products and inks and toners. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals and .

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, industrial spraying, roller or brushing applications and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: use personal protective equipment as required.; do not handle until all safety precautions have been read and understood; use only outdoors or in a well-ventilated area.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Abbott Ireland, Ballytivnan ROI Sligo Connaught Ireland
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Operations GmbH - ME01, Rellinghauser Straße 1-11 45128 Essen Germany
  • Intertek Deutschland GmbH TTCT, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Only representative (No publishable name), null
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France

Substance names and other identifiers

1,1,3-Trimethyl-3-cyclohexene-5-one
Other
2-Cyclohexen-1-one, 3,5,5-trimethyl-
Other
3,5,5-Trimethyl-2-cyclohexen-1-on
Other
3,5,5-Trimethyl-2-cyclohexen-1-one
Other
3,5,5-Trimethyl-2-cyclohexenone
Other
3,5,5-trimethylcyclohex-2-enone
EC Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other
3,5,5-Trimethylcyclohex-2-enone
Substance Evaluation - CoRAP, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
3,5,5-trimethylcyclohex-2-enone isophorone
C&L Inventory
3,5,5-trimethylcyclohex-2-enone; isophorone
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
3,5,5-Trimetil-2-cicloesen-1-one
Other
Isoacetophorone
Other
Isoforon
Other
Isoforone
Other
Isooctopherone
Other
Isophorone
Other
Izoforon
Other
3,5,5-trimethylcyclohex-2-enon isoforon (nl)
C&L Inventory
3,5,5-Trimethylcyclohex-2-enon Isophoron (de)
C&L Inventory
3,5,5-trimethylcyclohex-2-enon isophoron (da)
C&L Inventory
3,5,5-trimethylcyklohex-2-en-1-on isoforon (cs)
C&L Inventory
3,5,5-trimetil, 2-ciclohexenona izoforona (ro)
C&L Inventory
3,5,5-trimetil-2-ciclohexeno-1-ona isoforona (pt)
C&L Inventory
3,5,5-trimetil-2-cikloheksen-1-on izoforon (sl)
C&L Inventory
3,5,5-trimetil-2-cikloheksen-1-onas izoforonas (lt)
C&L Inventory
3,5,5-trimetilcicloes-2-enone isoforone (it)
C&L Inventory
3,5,5-trimetilciclohex-2-enona isoforona (es)
C&L Inventory
3,5,5-trimetilcikloheks-2-enons, izoforons (lv)
C&L Inventory
3,5,5-trimetilciklohex-2-én-1-on izoforon (hu)
C&L Inventory
3,5,5-trimetylcykloheks-2-enon isoforon (no)
C&L Inventory
3,5,5-trimetylcyklohex-2-enón izoforón (sk)
C&L Inventory
3,5,5-trimetylocykloheks-2-en-1-on izoforon (pl)
C&L Inventory
3,5,5-trimetyylisykloheks-2-enoni isoforoni (fi)
C&L Inventory
3,5,5-trimetüültsükloheks-2-enoon Isoforoon (et)
C&L Inventory
3,5,5-triméthylcyclohex-2-énone; isophorone isophorone (fr)
C&L Inventory
3,5,5-τριμεθυλοκυκλοεξ-2-ενόνη ισοφορόν (el)
C&L Inventory
3,5,5-триметилциклохекс-2-eнон изофорон (bg)
C&L Inventory
isoforon 3,5,5-trimetyl-2-cyklohexen-1-on (sv)
C&L Inventory
1,1,3-Trimethyl-3-cyclohexene-5-one
C&L Inventory
3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE
C&L Inventory
3,5,5-Trimethyl-2-cyclohexene-1-one
C&L Inventory, Registration dossier
3,5,5-Trimethylcyclohex-2-en-1-on
Registration dossier
3,5,5-trimethylcyclohex-2-en-1-one
C&L Inventory, Registration dossier, Other
3,5,5-trimethylcyclohex-2-en-1-one.
C&L Inventory
3,5,5-Trimethylcyclohex-2-enone
C&L Inventory
3,5,5-trimethylcyclohex-2-enone isophorone
C&L Inventory
3,5,5-trimethylcyclohex-2enone; isophorone
C&L Inventory
3,5,5-trimethylcyclohexen-2-one
C&L Inventory
Isophorone
C&L Inventory, Registration dossier
Isophorone
C&L Inventory, Registration dossier
1,1,3-trimethyl-3-cyclohexen-5-one
Registration dossier
1,1,3-Trimethyl-3-cyclohexene-5-one
Registration dossier
1,5,5-Trimethyl-3-oxocyclohexene
Registration dossier
alpha-Isophoron
Registration dossier
alpha-Isophorone
Registration dossier
Isoacetophorone
Registration dossier
isoforone
C&L Inventory
Isophorone
Registration dossier
606-012-00-8
Index number
C&L Inventory
78-59-1
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Liquid (100%) [1]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Liquid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 4 studies processed
R Melting / freezing point
-8.1 - -8 °C @ 101.3 kPa [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-8.1 - -8 °C

Boiling point

Study results
  • 8 studies submitted
  • 8 studies processed
R Boiling point
213.28 - 215.5 °C @ 101.3 - 101.33 kPa [8]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
215.1 - 215.3 °C

Density

Study results
  • 8 studies submitted
  • 8 studies processed
R Density
0.92 - 0.923 g/cm³ @ 20 °C [7]
R Relative density
0.925 @ 20 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.921 - 0.921

Vapour pressure

Study results
  • 9 studies submitted
  • 5 studies processed
R Vapour pressure
0.02 - 58 Pa @ 20 - 25 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
40 Pa @ 20 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 2 studies processed
R Log Pow
1.67 - 1.7 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
1.67 - 1.7 @ 20 °C

Water solubility

Study results
  • 7 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
12 - 14.5 g/L @ 20 - 25 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
12 - 14.5 g/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 7 studies submitted
  • 7 studies processed
R Flash point
82 - 104 °C @ 101.3 kPa [7]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 7
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
85.05 °C

Auto flammability

Study results
  • 5 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
460 - 470 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
460 °C

Flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
Non oxidising (50%), No (50%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
1.7 - 2.61 [2]
R kinematic viscosity (in mm²/s)
1.88 - 2.83 [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
2.83 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
4.8 h [1]
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
23 min
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 12 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 6 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
7

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 2 studies processed
R Koc
65.15 - 115.1 L/kg @ 25 °C [2]
R log Koc
1.81 - 2.06 dimensionless @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
58.3

Henrys law constant (H)

Study results
  • 6 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0.668 Pa m³/mol [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
0.38 - 0.668 Pa.m³.mol-1 @ 20 - 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 89 µg/L (1)
Intermittent releases (freshwater) 1.2 mg/L (1)
Marine water 8.9 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (1)
Sediment (freshwater) 839 µg/kg sediment dw (1)
Sediment (marine water) 83.9 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 120 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 12 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 140 - 228 mg/L [3]
EC50 (4 days) 217 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 2 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
NOEC (35 days) 11 mg/L [1]
NOEC (32 days) 4.2 - 15.6 mg/L [1]
LOEC (35 days) 19 mg/L [1]
LOEC (32 days) 8.8 - 22.7 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 224 mg/L [1]
LC50 (48 h) 120 mg/L [1]
LC50 (24 h) 430 mg/L [1]
NOEC (48 h) 15 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 475 mg/L [2]
NOEC (14 days) 29.9 - 49.8 mg/L [2]
LOEC (14 days) 49.8 - 83.07 mg/L [2]
EC10 (72 h) 64 mg/L [2]
EC90 (72 h) 1 g/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
475 mg/L
EC10 or NOEC for freshwater algae
64 mg/L
EC10 or NOEC for marine water algae
29.9 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
100 mg/L
EC10 or NOEC for microorganisms
435 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 748 - 79 800 µg/L [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11 mg/m³ -
Acute /short term: (DNEL) 22 mg/m³ -
Local Effects
Long-term: (DNEL) 11 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 22 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 13 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 52 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 700 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 700 µg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 700 µg/m³ -
Acute /short term: (DNEL) 700 µg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 325 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 325 µg/kg bw/day repeated dose toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 15
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Dermal: 5 %

Acute toxicity

Study results
oral
  • 14 studies submitted
  • 2 studies processed
P/RResults
LD50 1 500 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 6
Data waiving
no waivers
inhalation
  • 19 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 7 mg/L air (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 2
Supporting study 14
Weight of evidence
Other 3
Data waiving
no waivers
dermal
  • 8 studies submitted
  • 2 studies processed
P/RResults
LD50 1 200 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

dermal
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 3
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LD50 1 500 mg/kg bw
Inhalation route:
Adverse effect observed LC50 7 mg/L air
Dermal route:
Adverse effect observed LD50 1 200 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 13 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 102.5 - 500 mg/kg bw/day [5]
NOAEL (rat): 1 500 - 3 000 ppm [2]
NOAEL (mouse): 125 - 1 000 mg/kg bw/day [5]

Type of Study provided
Study data: oral
Studies with data
Key study 8
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 11 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 208 - 1 436 mg/m³ air [2]
NOAEC (mouse): 513 mg/m³ air [1]
NOAEC (rabbit): 1.436 mg/L air [1]

Study data: inhalation
Studies with data
Key study 6
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 102.5 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 208 mg/m³ (subacute, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 208 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 35 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 16
Supporting study 14
Weight of evidence
Other 2 3
Data waiving
no waivers
Study data: in vivo
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 2 873 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 289 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint