Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-193-3
CAS no.:
54-11-5
Index number:
Molecular formula:
C10H14N2
SMILES:
CN1CCC[C@H]1C1=CN=CC=C1
InChI:
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance is fatal if swallowed, is fatal in contact with skin, is fatal if inhaled and is toxic to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes serious eye damage and causes skin irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life.

Breakdown of all 443 C&L notifications submitted to ECHA

Aquatic Chronic 2 H411 Harmonised Classification
Acute Tox. 1 H310
Acute Tox. 2 H300 Harmonised Classification
Acute Tox. 2 H330 Harmonised Classification
Acute Tox. 3 H301
Acute Tox. 2 H310 Harmonised Classification
Aquatic Acute 1 H400
Eye Dam. 1 H318
Skin Irrit. 2 H315
Acute Tox. 3 H311
Acute Tox. 3 H331
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
This substance is subject to the Prior Informed Consent regulation and to export notification procedure from 31-Jan-2005
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals.

This substance is used in the following areas: scientific research and development.

This substance is used in the following activities or processes at workplace: laboratory work.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

This substance is used in the following products: laboratory chemicals and pharmaceuticals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, transfer of substance into small containers, laboratory work, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, roller or brushing applications and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: laboratory chemicals and pharmaceuticals.

This substance is used in the following areas: scientific research and development and health services. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, laboratory work, mixing in open batch processes, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Immediately call a poison center or doctor/physician. If on skin: wash with soap and water.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • A-sense Sp. z o.o. , Mościckiego 1 24-100 Puławy Poland
  • CHEMNOVATIC R&D Sp. z o.o., Turystyczna 9 20-207 Lublin Poland
  • Chemservice GmbH - (A2C5), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Contraf-Nicotex-Tobacco GmbH, Herbststr. 8 74072 Heilbronn Germany
  • GAIATREND, 10, route de Strasbourg 57410 ROHRBACH LES BITCHE France
  • HiLIQ Bartosz Blak, Drewnowskiego 5/4 05-131 Zegrze Poland
  • Nicobrand, 189 Castleroe Road BT51 3RP Coleraine Londonderry United Kingdom
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21, FI-02600 Espoo Finland
  • Sustainability Support Services (Europe) AB (acting as OR for BGP Healthcare Pvt. Ltd., India), Markaskälsvägen 6 22647 Lund Sweden

Substance names and other identifiers

nicotine (ISO);3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
C&L Inventory
(S)-3-(1-metil-2-pirolidinil)piridin (sl)
C&L Inventory
3-(1-methylpyrrolidin-2-yl)pyridin (cs)
C&L Inventory
3-(<I>N</I>-metil-2-pirolidinil)piridin (hr)
C&L Inventory
3-(N-methyl-2-pyrrolidinyl)pyridin (de)
C&L Inventory
3-(N-metil-2-pirolidinil)piridina (ro)
C&L Inventory
3-(N-metil-2-pirolidinil)piridinas (lt)
C&L Inventory
3-(N-metil-2-pirolidinil)piridīns (lv)
C&L Inventory
3-(N-metil-2-pirrolidinil)piridin (hu)
C&L Inventory
3-(N-metylopirolidyn-2-ylo)pirydyna (pl)
C&L Inventory
3-(N-metylpyrolidín-2-yl)pyridín (sk)
C&L Inventory
3-(N-metüül-2-pürrolidinüül)püridiin (et)
C&L Inventory
3-(N-метил-2-пиролидинил)пиридин (bg)
C&L Inventory
nicotin (da)
C&L Inventory
Nicotin (ISO) (de)
C&L Inventory
nicotina (es)
C&L Inventory
nicotina (ISO) (ro)
C&L Inventory
nicotine (fr)
C&L Inventory
nicotine (ISO) (bg)
C&L Inventory
nikotiin (ISO) (et)
C&L Inventory
nikotiini (fi)
C&L Inventory
nikotin (no)
C&L Inventory
nikotin (ISO) (hr)
C&L Inventory
nikotinas (ISO) (lt)
C&L Inventory
nikotyna (pl)
C&L Inventory
nikotín (ISO) (sk)
C&L Inventory
nikotīns (ISO) (lv)
C&L Inventory
νικοτίν (el)
C&L Inventory
Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-
Other
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
C&L Inventory
(ISO)-3-[1-Methylpyrrolidin-2-yl]pyridine
C&L Inventory
(S)-3-(1-methyl-2-pyrrolidinyl) pyridine
C&L Inventory
(S)-3-(1-méthyl- 2-pyrrolidinyl)pyridine
C&L Inventory
(S)-3-[1-Methylpyrrolidin-2-yl]pyridine
C&L Inventory
(S)-3-[2-(N-methylpyrrolidin-2-yl)pyrydine
C&L Inventory
3 - (N-methyl-2-pyrrolidinyl) pyridinu
C&L Inventory
3- (N-methyl-2-pyrrolidinyl) pyridin
C&L Inventory
3-(1-methyl-2-pyrrolidinyl)pyridine
C&L Inventory
3-(1-methylpyrrolidin-2-yl)pyridine
C&L Inventory, Registration dossier
3-(N-methyl-2-pyrrolidinyl)Pyridine
C&L Inventory
3-[(2s)-1-methyl-2-pyrrolidinyl]pyridine
C&L Inventory
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
C&L Inventory, Registration dossier, Other
ISO)-3-[1-Methylpyrrolidin-2-yl]pyridine
C&L Inventory
NIC - H2O
C&L Inventory
nicotine (ISO); 3-(N-methyl-2-pyrrolidinyl)pyridine
C&L Inventory
Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-
C&L Inventory
Reaction mass of 56-81-5 and 57-55-6
C&L Inventory
Nicotine E Liquids
C&L Inventory
Nicotine USP/EP
Registration dossier
13890-81-8
Deleted CAS number
Other
13890-82-9
Deleted CAS number
Other
16760-37-5
Deleted CAS number
Other
2939 99 00
CN Code
PIC
54-11-5
CAS number
EC Inventory, C&L Inventory, PIC, Registration dossier, REACH pre-registration, Other
551-13-3
Deleted CAS number
Other
614-001-00-4
Index number
C&L Inventory
6912-85-2
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Other (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-79 °C

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
248.8 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
248.8 °C

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.01 g/cm³ @ 20 °C [1]
R Relative density
1.01 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.01

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
5.81 - 8.83 Pa @ 20 - 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
5.81 Pa @ 20 °C

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
-2.67 - 1.17 @ pH 2.01 - 12.17 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.17 @ 18 °C

Water solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
100 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 1 study processed
R Flash point
111 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
111 °C

Auto flammability

Study results
  • 1 study submitted
  • 1 study processed
R Autoflammability / self-ignition
240 °C @ 99.451 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
240 °C

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 400 ng/L (1)
Intermittent releases (freshwater) 30 µg/L (1)
Marine water 40 ng/L (1)
Intermittent releases (marine water) 3 µg/L (1)
Sewage treatment plant (STP) 2.7 mg/L (1)
Sediment (freshwater) 650 ng/kg sediment dw (1)
Sediment (marine water) 65 ng/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 321 ng/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (4 days) 3 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
3 mg/L

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 3 mg/L [1]
EC50 (24 h) 3.75 mg/L [1]
NOEC (48 h) 2.1 mg/L [1]
LOEC (48 h) 4.5 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
3 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (16 days) 20 - 120 µg/L [2]
LOEC (16 days) 70 - 180 µg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
20 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 11 - 37 mg/L [2]
NOEC (72 h) 3.2 mg/L [2]
LOEC (72 h) 10 mg/L [2]
EC10 (72 h) 5.2 - 5.3 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
11 mg/L
EC10 or NOEC for freshwater algae
5.2 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 27 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
27 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 31.3 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 8.6 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.43 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 840 µg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 200 µg/cm² skin irritation/corrosion
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.56 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 6.4 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.597 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 1.1 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 100 µg/cm² skin irritation/corrosion
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.4 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 76.7 µg/kg bw/day acute toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 4 studies processed
P/RResults
LD50 68 - 71 mg/kg bw (rat) [4]
LD50 77.83 mg/kg bw (mouse) [1]
M/CInterpretations of results
Toxicity Category III [3]

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (20 min) 2.3 mg/L air (rat) [1]
M/CInterpretations of results
Category 2 based on GHS criteria [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 70.4 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Toxicity Category II [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 9 mg/kg bw
Inhalation route:
Adverse effect observed LC50 190 mg/m³
Dermal route:
Adverse effect observed LD50 70.4 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irreversible damage)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 10 mg/m³ air [1]
LOAEC (rat): 10 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route - systemic effects:
Adverse effect observed LOAEC 10 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 20 mg/m³ (subacute, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 20 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant