Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 800-182-9 | CAS number: 1426148-68-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-Across of experimental data from analogius compounds based on expert judgement.
Data source
Reference
- Reference Type:
- publication
- Title:
- The absorption, distribution and excretion of alkyl polyethoxylates by rats and humans
- Author:
- Drotmann
- Year:
- 1 980
- Bibliographic source:
- Tox. Appl. Pharmacol. 52: 38-44
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigation of absorption, distribution and excretion following oral and dermal application
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethoxylated alcohol (C12/13 with 6 EO)
- IUPAC Name:
- Ethoxylated alcohol (C12/13 with 6 EO)
- Test material form:
- other: depending on application form
- Details on test material:
- Ethoxylated alcohol (C12/13 with 6 EO)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: human
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: non-occlusive metal shield
- Vehicle:
- ethanol
- Duration of exposure:
- 8 hours
- Doses:
- 100 mg dissolved in 1 mL ethanol per person
- Details on study design:
- see summary
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
- Total recovery:
- Total recovery of the applied radioactivity was between 82.4% (subject 1) and 94.7% (subject 2). Most of the activity was located on the skin at the application site (73.9% for subject 1; 87.5% for subject 2).
Applicant's summary and conclusion
- Conclusions:
- The ethoxylated alcohol under investigation was absorbed only poorly through human skin and much less readily than through rat skin.
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