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Diss Factsheets
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EC number: 203-989-9 | CAS number: 112-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- Tetraethylene glycol was obtained from Texas City, TX plant (sample # 48-349). No further details provided.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley albino rats, weighing between 200 and 300 g, were used.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapor is produced by passing air (at 2.5 liters/min) through the sample and then through a 9-liter animal chamber (dynamic conditions).
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Described as substantially saturated vapor generated at 24C.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- Rats were weighed prior to exposure to the test material and again on day 7 and 14. Animals were observed for clinical symptoms and mortality. At the end of the 14 day observation period, a gross pathologic examination of the rats was conducted.
- Statistics:
- Body weight mean and S.D. were calculated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.06 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- No mortality was observed in males or females exposed to a substantially saturated vapor concentration.
- Clinical signs:
- other: No clinical signs were observed in males or females exposed to a substantially saturated vapor concentration.
- Body weight:
- Male rats gained weight on days 7 and 14 from pre-exposure values (Table 1). Females remained essentially the same throughout the 14 day observation period.
- Gross pathology:
- There were no treatment-related gross pathologic observations.
- Other findings:
- Using a vapor pressure of 0.0000465 mm Hg at 25C corresponds to a saturated vapor concentration of 0.061 ppm.
Any other information on results incl. tables
Table 1 Body weights of Males and Females exposed to a substantially saturated vapor concentration for 6 hours.
Day 0 | Day 7 | Day 14 | |
Males | 237 + 2.4 | 261 + 5.7 | 282 + 7.9 |
Females | 256 + 7.2 | 257 + 8.9 | 256 + 8.4 |
Applicant's summary and conclusion
- Conclusions:
- A single dynamic inhalation exposure to substantially saturated vapor for a 6-hour period produced no deaths or other signs of toxicity among male and female rats.
- Executive summary:
Groups of 5 male and 5 female rats were exposed to a substantially saturated vapor concentration for 6 hours. There were no effects on mortality, body weight, clinical symptoms or gross pathology noted in rats.
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