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EC number: 203-989-9 | CAS number: 112-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There was no lethality noted in rats dosed orally with 16 ml/kg (~18,000 mg/kg) or rabbits dosed dermally with 16 ml/kg (~18000 mg/kg) tetraethylene glycol for 24 hours in most recent key studies. Mellon Institute UCC 1940 study arrived at lowest oral LD50 value of 30000 mg/kg bw that was used as the basis for LD50 value presented. Linkewise, dermal LD50 value of 20 ml/kg (~22600 mg/kg bw) derived by the UCC 1972 study was used as the basis for dermal LD50 value.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley albino rats, weighing between 200 and 300 g were used. The rats are fasted overnight before dosing.
The animals are maintained on appropriate commercial diet and municipal water. Both are available ad libitum except during periods of fasting (rat peroral test) or manipulation. - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The maximum dosage for the peroral test is 16 ml/kg. Based on the test results, no additional dose levels were examined.
- Doses:
- 16 ml/kg
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- not specified
- Details on study design:
- Animal weights are recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice). At death or sacrifice, each animal is subjected to gross pathologic evaluation.
- Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983) and are based on a 14-day observation period.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Based on:
- test mat.
- Mortality:
- None of 5 males or 5 females died from this dosage.
- Clinical signs:
- other: There were no signs of toxicity observed.
- Gross pathology:
- There were no remarkable gross pathologic lesions observed.
- Other findings:
- No additional information available.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for male and female rats receiving single peroral doses of tetraethylene glycol was greater than 16.0 ml/kg (>18000 mg/kg).
- Executive summary:
The acute oral toxicity of tetraethylene glycol was examined.
The LD50 for male and female rats receiving single peroral doses of tetraethylene glycol was greater than 16.0 ml/kg, Rats gained weight with no clinical signs of toxicity. There were no remarkable gross pathological lesions observed.
Reference
No additional information available.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 30 000 mg/kg bw
- Quality of whole database:
- Although the database is quite old, the results demonstrate that lethality is observed only at very high doses.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley albino rats, weighing between 200 and 300 g, were used.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapor is produced by passing air (at 2.5 liters/min) through the sample and then through a 9-liter animal chamber (dynamic conditions).
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Described as substantially saturated vapor generated at 24C.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- Rats were weighed prior to exposure to the test material and again on day 7 and 14. Animals were observed for clinical symptoms and mortality. At the end of the 14 day observation period, a gross pathologic examination of the rats was conducted.
- Statistics:
- Body weight mean and S.D. were calculated.
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.06 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- No mortality was observed in males or females exposed to a substantially saturated vapor concentration.
- Clinical signs:
- other: No clinical signs were observed in males or females exposed to a substantially saturated vapor concentration.
- Body weight:
- Male rats gained weight on days 7 and 14 from pre-exposure values (Table 1). Females remained essentially the same throughout the 14 day observation period.
- Gross pathology:
- There were no treatment-related gross pathologic observations.
- Other findings:
- Using a vapor pressure of 0.0000465 mm Hg at 25C corresponds to a saturated vapor concentration of 0.061 ppm.
- Conclusions:
- A single dynamic inhalation exposure to substantially saturated vapor for a 6-hour period produced no deaths or other signs of toxicity among male and female rats.
- Executive summary:
Groups of 5 male and 5 female rats were exposed to a substantially saturated vapor concentration for 6 hours. There were no effects on mortality, body weight, clinical symptoms or gross pathology noted in rats.
Reference
Table 1 Body weights of Males and Females exposed to a substantially saturated vapor concentration for 6 hours.
Day 0 | Day 7 | Day 14 | |
Males | 237 + 2.4 | 261 + 5.7 | 282 + 7.9 |
Females | 256 + 7.2 | 257 + 8.9 | 256 + 8.4 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- A saturated vapor is quite low, 0.061 ppm (0.49 ug/L) with no mortality noted.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- New Zealand White rabbits, weighing between 2.0 and 3.0 kg, were used. The animals are maintained on appropriate commercial diet and municipal water.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Rabbits were subjected to 24 hours of contact with the test material which is retained under impervious sheeting on the clipped, intact skin of the trunk. As necessary for larger doses, gauze is wrapped around the trunk over the sample to prevent leakage. Vetrap® Bandaging Tape is wrapped over the impervious sheeting and the animal is returned to its cage for the contact period.
- Duration of exposure:
- 24 hours
- Doses:
- 16 ml/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- After the contact period, excess fluid is removed to diminish ingestion. Observations for skin reaction are made at one hour, 7 days and 14 days after the contact period. Five male and 5 females are included on each level used for the LD50 calculation. Animal weights are recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice). At death or sacrifice, each animal is subjected to gross pathologic evaluation.
- Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983) and are based on a 14-day observation period.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality noted in male or female rabbits exposed dermally to 16 ml/kg tetraethylene glycol for 24 hours.
- Clinical signs:
- other: In male rabbits ,sample residue and edema were observed at day 1. In females rabbits, sample residue, edema and erythema where observed on day 1.
- Gross pathology:
- There were no treatment related gross pathologic observations in male or female rabbits.
- Other findings:
- No additional information available.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Tetraethylene Glycol had an extremely low order of toxicity following single dermal application. LD50 was greater than 16ml/kg (>18000mg/kg).
- Executive summary:
The acute dermal toxicity of tetraethylene glycol was examined using New Zealand White rabbits. Tetraethylene Glycol had an extremely low order of toxicity following single dermal application. LD50 was greater than 16ml/kg (>18000mg/kg).
Reference
Table 1 Male and female rabbit body weights following a 24 hour dermal exposure to tetraethylene glycol.
Day 0 | Day 7 | Day 14 | |
Males | 2679 + 270 | 2743 + 342 | 2846 + 344 |
Females | 2775 + 174 | 2820 + 204 | 3011 + 224 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 22 600 mg/kg bw
- Quality of whole database:
- Although the database is old, the results demonstrate that lethality is observed only at very high doses.
Additional information
There was no lethality noted in rats dosed orally with 16 ml/kg (~18,000 mg/kg) or rabbits dosed dermally with 16 ml/kg (~18000 mg/kg) tetraethylene glycol for 24 hours in most recent key studies. Mellon Institute UCC 1940 study arrived at lowest oral LD50 value of 30000 mg/kg bw that was used as the basis for LD50 value presented. Linkewise, dermal LD50 value of 20 ml/kg (~22600 mg/kg bw) derived by the UCC 1972 study was used as the basis for dermal LD50 value.
Justification for selection of acute toxicity – oral endpoint
Most recent study with acceptable experimental detail information included and performed in accordance to guidelines.
Justification for selection of acute toxicity – inhalation endpoint
Most recent study with acceptable experimental detail information included.
Justification for selection of acute toxicity – dermal endpoint
Most recent study with acceptable experimental detail information included.
Justification for classification or non-classification
Based on study data and low acute toxicity for oral, inhalation and dermal endpoints, the Classification according to GHS and the Directive 67/548/EEC (DSD) is not warranted.
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