Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available (further information necessary)

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available (further information necessary)

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No repeated dose toxicity data are available for 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane and there are no suitable read-across data. A 90-day repeated dose toxicity study by the inhalation route is therefore proposed for the registered substance.

Justification for classification or non-classification

In the absence of data, 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane is not classified for systemic organ toxicity following repeated exposure according to Regulation (EC) No 1272/2008.