Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available (further information necessary)
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

There are no studies of reproductive toxicity for 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane. A 90-day repeated dose and a pre-natal developmental toxicity study are proposed. The need for additional studies on reproductive toxicity will be assessed when the results of those studies are available.

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available (further information necessary)
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

There are no developmental toxicity studies for 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane and no suitable read-across data are available. A pre-natal developmental toxicity study is therefore proposed.

Justification for classification or non-classification

In the absence of data, 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane is not classified for reproductive or developmental toxicity according to Regulation (EC) No 1272/2008.