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EC number: 221-660-8 | CAS number: 3179-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
An additional bacterial mutagenicity study is available (Kennelly JC (1988)). Negative results were obtained when 3-(diethoxymethylsilyl)propylamine was tested in Salmonella typhimurium strains TA 97, TA 98 and TA 100. This study was considered to be reliability 4 as only three strains of bacteria were tested, and only 2-aminoanthracene was used as the positive control in the presence of metabolic activation. The more reliable study was selected as key.
Information on potential for cytogenicity is available from a reliable study on 3-(diethoxymethylsilyl)propylamine conducted according to a Japanese standard method that is equivalent to OECD 473 and under GLP conditions (Shyouzou (2003)). Dose related increases in the number of CHL/IU cells with aberrations were observed with and without metabolic activation. It was observed that the pH of the culture medium increased at higher concentrations of test material, so the test was repeated with a more strongly buffered test medium. It was still not possible to control the pH of the cell growth medium fully. It was the opinion of the author of the report (as summarised by a Japanese speaker) that although the pH was increased in cultures showing increased frequency of cells with chromosome aberrations, as the effect was seen both with and without metabolic activation, this did not invalidate the positive result and the test material was concluded to be clastogenic.
The structural analogue substance, 3-aminopropyltriethoxysilane, has been tested in a reliable mammalian mutagenicity assay according to OECD TG 476 and under GLP (Krueger N (1998)). The original study was considered reliability 1. Read-across to the registered substance is considered scientifically justified and is reliability 2. Expected results were obtained from medium and positive controls. The results from the repeat experiment were consistent with those from the initial test. No increase in the mutant frequency was observed in Chinese hamster Ovary (CHO) cells in the absence of activation. In the presence of activation, a statistically significant increase was observed at a single concentration. As this result was within the range of the mutant frequencies of the historical negative controls, and no dose response relationship was observed, the increases are a result of normal assay variation rather than a mutagenic effect of the test substance. It is the opinion of the reviewer that although the test substance hydrolyses in water, and so the use of aqueous cell culture medium may have led to exposure of the test organisms to the products of hydrolysis rather than the test substance itself, this does not invalidate the test, as hydrolysis would occur in exposed organisms. It is concluded that the test substance in not mutagenic to mammalian cells under the conditions of the test.
3 -Aminopropyltriethoxysilane (Silane A-1100 CAS No. 919-30-2) has been tested in a reliable mouse micronucleus assay according to a protocol that is similar to OECD TG 474 and under GLP (BRRC (1998)). No treatment related increases in numbers of micronuclei in PCEs in Swiss-Webster mice were observed. Relatively high dose levels of the substance were tested by intraperitoneal administration up to 80% of the LD50 with no indication of a positive induction of micronuclei. The test substance was considered to be inactive as a clastogenic agent under the statistical criteria used. It is concluded that the test substance is negative for the induction of chromosome aberrations under the conditions of the test.
Although an increase in cells with aberrations was observed in vitro, no effect was observed when the analogous substance was tested in an in vivo micronucleus assay, so it is concluded that 3-(diethoxymethylsilyl)propylamine is not genotoxic.
Short description of key information:
Information is available for 3-(diethoxymethylsilyl)propylamine from reliable in vitro studies on mutagenicity to bacteria and cytogenicity to mammalian cells. No information is available for other in vitro or in vivo genetic toxicity endpoints for 3-(diethoxymethylsilyl)propylamine, however, studies are available for the related substance 3-aminopropyltriethoxysilane (CAS 919-30-2).
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without metabolic activation in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and Escherichia coli WP2 (similar to OECD TG 471) (Hita Research Laboratory (2003)).
Cytogenicity in mammalian cells: positive with and without metabolic activation in CHL/IU cells (similar to OECD TG 473) (Shyouzou (2003)).
Mutagenicity in mammalian cells: read across from analogous substance CAS 919-30-2: negative in CHO K1 cells (OECD TG 476) (Krueger N (1998)).
In vivo:
Micronucleus assay: read across from analogous substance 3- aminopropyltriethoxysilane CAS 919-30-2: Negative (ip study in mouse) (similar to OECD TG 474) (BRRC (1998)).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available in vitro and in vivo genotoxicity data, 3-(diethoxymethylsilyl)propylamine is not classified for mutagenicity according to Regulation (EC)1272/2008.
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