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EC number: 221-660-8 | CAS number: 3179-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21.11.1989 to 12.12.1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study conducted in accordance with the OECD guideline but without GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- none evident based on translation of German report
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-(diethoxymethylsilyl)propylamine
- EC Number:
- 221-660-8
- EC Name:
- 3-(diethoxymethylsilyl)propylamine
- Cas Number:
- 3179-76-8
- Molecular formula:
- C8H21NO2Si
- IUPAC Name:
- (3-aminopropyl)diethoxymethylsilane
- Details on test material:
- - Name of test material (as cited in study report): DYNASYLAN 1505 (3-aminopropyl)diethoxymethylsilan
- Substance type: Alkoxysilane
- Physical state: Liquid
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomas GmbH, Biberach, GERMANY
- Age at study initiation: not stated
- Weight at study initiation: 2.4 kg
- Housing: not identified from report in German
- Diet: standard diet ad libitum
- Water: drinking water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-1
- Humidity (%): 60 +/-5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 h/12 h
IN-LIFE DATES: not clear. Test began 1989-11-21 and ended 1989-12-12
Test system
- Type of coverage:
- other: covered application. It is not clear from the German report whether the material used was occlusive or semi-occlusive. If the study followed OECD 404, as indicated, it would have been semi-occlusive.
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 cm3 - Duration of treatment / exposure:
- 4 h (1h, 3 minutes - no further details)
- Observation period:
- observed at 1, 24, 48, 73 h following 4-h exposure. No 14-day follow-up observation due to corrosive effects.
- Number of animals:
- 1 (No details are given on additional animals, if any, used for the 1-h and 3-minute exposures. )
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal
- % coverage: not stated
- Type of wrap if used: unclear from German report
REMOVAL OF TEST SUBSTANCE
- Washing: gently rinsed with warm water
- Time after start of exposure: 4h.
SCORING SYSTEM: grading according to OECD 404.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema and oedema
- Basis:
- animal #1
- Remarks:
- exposure for 4 h
- Time point:
- other: 24, 48 and 72 h (mean)
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- 4-h exposure caused immediate grade 4/4 oedema and erythema in the single animal tested at all observation times following treatment (1, 24, 48 and 72 h). Necrosis and hardened skin were also reported. Due to the severe corrosive effects the observation was stopped at 72 hours. Exposure for 1 h also resulted in necrosis, but exposure for 3 minutes did not. Full data are not given for these shorter exposure periods.
- Other effects:
- None stated
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test.
Score at time point / Reversibility |
Erythema |
Edema |
Necrosis |
Hardening of skin |
Max. score: 4 |
Max. score: 4 |
|||
1 h |
4 |
4 |
yes |
|
24 h |
4 |
4 |
yes |
yes |
48 h |
4 |
4 |
yes |
yes |
72 h |
4 |
4 |
yes |
yes |
Average 24h, 48h, 72h |
4 |
4 |
||
Average 1h, 24h, 48h, 72h |
4 |
4 |
Reversibility not assessed as study terminated at 72 h due to corrosive effects.
Based on single animal exposed for 4 h.
Applicant's summary and conclusion
- Interpretation of results:
- other: Likely to be Cat 1B
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In a skin irritation/corrosion study conducted in accordance with OECD 404 but not GLP (reliability score 2), the test substance was found to be corrosive to the skin of a single rabbit (grade 8/8) following a 4-hour exposure. Necrosis was also observed following a 1-hour but not a 3-minute exposure (extremely limited details on the 1-hour and 3 minute exposures).
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