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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation, other
Type of information:
mixture rules calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
other: Guidance
Title:
Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
Author:
ECHA
Year:
2017
Bibliographic source:
ECHA-17-G-21-EN

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:

Classification based on calculation rules for mixtures of the CLP Regulation
GLP compliance:
not specified
Remarks:
Calculation method
Type of study:
other: Calculation method

Test material

Constituent 1
Reference substance name:
Curcuma longa, essential oil obtained by steam distillation of the leaves
Molecular formula:
No applicable for UVCB substance
IUPAC Name:
Curcuma longa, essential oil obtained by steam distillation of the leaves
Test material form:
liquid

Results and discussion

In vitro / in chemico

Results
Key result
Parameter:
other: classification
Remarks on result:
other: Skin sensitizer category 1

Any other information on results incl. tables

Multiple constituents of Turmeric leaf oil have been classified as Skin Sensitiser Cat. 1 or Cat 1B (see table) and are all present or potentially present above the CLP concentration limit of 1%. Therefore, Turmeric oil shall be classified as a skin sensitizer without further testing according to the Regulation (EC) No 1272/2008 .





















































ConstituentCAS#Typical Concentration, %CLP
ALPHA-PHELLANDRENE99-83-255.85Skin Sens. 1B
TERPINOLENE586-62-911.33Skin Sens. 1B
EUCALYPTOL470-82-66.6Skin Sens. 1B
LIMONENE138-86-32.92Skin Sens. 1
ALPHA-PINENE80-56-82.72Skin Sens. 1
BETA-PINENE127-91-32.72Skin Sens. 1B
ALPHA-TERPINENE99-86-51.02Skin Sens. 1B

 

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Remarks:
in accordance with EU CLP (EC 1272/2008 and its updates)
Conclusions:
Turmeric leaf oil contains constituents that are classified as skin sensitizers Cat.1 and Cat 1B and are all potentially present above the CLP generic concentration limit of 1% that triggers classification of the mixture. Therefore, the registered substance is classified as a skin sensitizer Cat. 1.
Executive summary:

Turmeric leaf oil contains constituents that are classified as skin sensitizers Cat.1 and Cat 1B and are all potentially present above the CLP generic concentration limit of 1% that triggers classification of the mixture. Therefore, the registered substance is classified as a skin sensitizer Cat. 1 according to the Regulation (EC) No 1272/2008.