Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- mixture rules calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- Turmeric Leaf Oil is a Natural Complex Substance and UVCB with a well-defined composition for which the relative percentage is known. The acute oral toxicity has been investigated using constituent approach and CLP additivity calculation.
Data source
Reference
- Reference Type:
- other: Guidance
- Title:
- Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
- Author:
- ECHA
- Year:
- 2 017
- Bibliographic source:
- ECHA-17-G-21-EN
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Classification based on calculation rules for mixtures of the CLP Regulation
- GLP compliance:
- not specified
- Remarks:
- Calculation method
Test material
- Reference substance name:
- Curcuma longa, essential oil obtained by steam distillation of the leaves
- Molecular formula:
- No applicable for UVCB substance
- IUPAC Name:
- Curcuma longa, essential oil obtained by steam distillation of the leaves
- Test material form:
- liquid
Constituent 1
Results and discussion
Effect levels
- Key result
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Calculated
Any other information on results incl. tables
| Constituent | CAS# | Typical Concentration, % | rat oral LD50, mg/kg bw | C/ATE calculation | Reference |
| ALPHA-PHELLANDRENE | 99-83-2 | 55.85 | 5700 | No category, not included for calculation | RIFM Reference No. 2536 |
| TERPINOLENE | 586-62-9 | 11.33 | 3740 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/10412/7/3/2 |
| EUCALYPTOL | 470-82-6 | 6.6 | 4500 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/13231/7/3/2 |
| P-CYMENE | 99-87-6 | 5.93 | 4750 | No category, not included for calculation | Jenner et al., Food and Cosmetics Toxicology, 1964, 2, 327-343 |
| MYRCENE | 123-35-3 | 3.17 | >5000 | No category, not included for calculation | REACH registration https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/14795/7/3/2/ |
| LIMONENE | 138-86-3 | 2.92 | >2000 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/15256/7/3/2 |
| ALPHA-PINENE | 80-56-8 | 2.72 | >500 | 0.00544 | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/14724/7/3/2 |
| BETA-PINENE | 127-91-3 | 2.72 | >5000 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/15934/7/3/2 |
| GAMMA-TERPINENE | 99-85-4 | 2.33 | >2000 | No category, not included for calculation | RIFM Reference No. 2021 |
| CARENE | 13466-78-9 | 1.2 | 4800 | No category, not included for calculation | RIFM Reference No. 2536 |
| ALPHA-TERPINENE | 99-86-5 | 1.02 | 1680 | 0.000607143 | RIFM Reference No. 2021 |
| Total | 95.79 | 0.006047143 |
ATEmix = 100 / 0.006047143 = 16537 mg/kg bw
Conclusion: LD50 >2000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Acute oral toxicity of the UVCB substance has been determined to be LD50 >2000 mg/kg bw by using the constituent approach and CLP additivity calculation.
- Executive summary:
Turmeric Leaf Oil is a Natrual Complex Substance and UVCB with well-defined composition. Its acute oral toxicity has been determined to be LD50 >2000 mg/kg bw by using the constituent approach and CLP additivity calculation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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