Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-696-7 | CAS number: 72490-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Mar 1982 to 31 Mar 1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- May 1981
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Version / remarks:
- Aug 1978
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate
- EC Number:
- 276-696-7
- EC Name:
- Ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate
- Cas Number:
- 72490-01-8
- Molecular formula:
- C17 H19 N O4
- IUPAC Name:
- ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- KFM-HAN
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 9 weeks
- Weight at study initiation: 198 - 234 g for males and 173 – 206 g for females
- Diet: Ad libitum (defined for acceptable contaminant levels)
- Water: tap water ad libitum (Quality according to the requirements of the Schweiz, lebensmittelbuch)
- Acclimation period: 1 week under test conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 10 Mar 1982 to 31 Mar 1992
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 400
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 20 mL/kg bw - Doses:
- 3000, 5000, 8000 and 10000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Animals were observed five times at day 1 and than daily for the nature onset severity and duration of all gross or visible toxic or pharmacological effects as well as rare and time of death.
- The animals were weighed at the day of dosing and day 7 and 14 after the administration.
- All test animals were subjected to a complete necropsy following their sacrifice or spontaneous death. All organs abnormalities were recorded. From the following organ of all animals histopathological evaluation was made: heart, lung, liver, kidneys, spleen. - Statistics:
- The Logit Model could not be applied to the observed rates of death. The LD50 was estimated without use of a statistic model.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2/5 females given 10000 mg/kg bw were found dead on day 2 after treatment. No further mortality occurred.
- Clinical signs:
- other: In all dose groups, rats showed sedation, dyspnoea, ventral or curved body position, latero-abdominal position, diarrhoea and ruffled fur. Rats given 5000 mg/kg or higher doses showed exophtalmos and slight spasms. Rats given 8000 and 10000 mg/kg showed s
- Gross pathology:
- In all dose groups, lesions in the lungs, liver and kidney were noted which are commonly seen in rats of this strain and age. Splenic haemopoiesis was seen in nearly all animals. Gastric ulcer was noted in one high-dose male. In the two females that died during the study, slight to moderate unicellular and multicellular necrosis of the liver was observed.
- Other findings:
- SYMPTOMS
The main symptoms observed in the different dose groups were:
3000 mg/kg bw: sedation, dyspnoea ventral-, latero-abdominal-, curved body position, diarrhoea ruffled fur.
5000 mg/kg bw: sedation, dyspnoea, exophthalmos, ventral-, latero abdominal- curved body position, spasms, diarrhoea ruffled fur.
8000 mg/kg bw: sedation, coma, dyspnoea, exophthalmos, ventral-, latero-abdominal-, curved body position, spasms, tremor, diarrhoea, ruffled fur.
10000 mg/kg bw: sedation, dyspnoea, exophthalmos, latero-abdominal, curved body position, spasms, tremor, loss of weight, diarrhoea ruffled fur.
The above mentioned symptoms were more pronounced in the higher dose groups. The surviving animals had recovered within 7 to 9 observation days.
NECROPSY
In two high-dose animals that died two days after the application, slight to moderate, unicellular and multicellular necrosis was noted in the liver.
Gastric ulcer was noted in one high-dose male.
Splenic haemopoiesis was noted in most animals of all groups,
A few other lesions observed in this study are commonly seen in rats of this strain and age.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of the test substance was found to be greater than 10000 mg/kg bw in both male and female rats.
- Executive summary:
Groups of 5 male and 5 female Wistar KFM-HAN rats received a single oral dose of 3000, 5000, 8000 and 10000 mg/kg bw of the test substance in a study performed according to OECD TG 401 following GLP principles. The animals were assessed daily for the following 14 days for any signs of systemic toxicity and their body weights were recorded at intervals throughout the study. All animals were subjected to a complete gross necropsy following their sacrifice or spontaneous death.
The following death rates were observed: 0 % at 3000 mg/kg bw, 0 % at 5000 mg/kg bw, 0 % at 8000 mg/kg bw and 20 % at 10000 mg/kg bw.
The acute oral LD50 of the test substance in rats of both sexes observed over a period of 14 days was estimated to be greater than 10000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.