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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 Sep 1993 to 12 Oct 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1981
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
1984
Qualifier:
according to guideline
Guideline:
other: US Federal Register 40 CFR part 796.1840
Version / remarks:
1985
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
7.9 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.1 g/L
Incubation duration:
>= 1 - <= 3 d
Temp.:
25 °C
pH:
>= 7.36 - <= 7.84

RESULTS

Table 2 Centrifugation at 30000 G, different pre-equilibration periods at 30 °C

sample number

W1

W4

W7

weight of test substance [mg] dispersed in 50.0 mL of water

5.084

5.084

5.084

number of days at 30 °C

3

2

1

number of days at 25 °C

1

1

1

Centrifugation [G]

30000

30000

30000

Centrifugationtime [min]

40

40

40

pH of aqueoussolution

7.48

7.71

7.55

water solubility [mg/L]

1.    determination

2.    determination

 

average

 

7.957

7.933

 

7.945

 

8.137

8.119

 

8.128

 

8.384

8.329

 

8.357

total average

8.143 mg/L

rel. standard deviation

2.3 %

 

Table 3 Centrifugation at 40000 G, different pre-equilibration periods at 30 °C

sample number

W2

W5

W8

weight of test substance [mg] dispersed in 50.0 mL of water

5.084

5.084

5.084

number of days at 30 °C

3

2

1

number of days at 25 °C

1

1

1

Centrifugation [G]

40000

40000

40000

Centrifugationtime [min]

40

40

40

pH of aqueoussolution

7.75

7.62

7.36

water solubility [mg/L]

1.    determination

2.    determination

 

average

 

7.945

7.897

 

7.921

 

8.069

8.046

 

8.058

 

8.173

8.190

 

8.182

total average

8.053 mg/L

rel. standard deviation

1.5 %

 

Table 4 Centrifugation at 50000 G, different pre-equilibration periods at 30 °C

sample number

W3

W6

W9

weight of test substance [mg] dispersed in 50.0 mL of water

5.084

5.084

5.084

number of days at 30 °C

3

2

1

number of days at 25 °C

1

1

1

Centrifugation [G]

50000

50000

50000

Centrifugationtime [min]

40

40

40

pH of aqueoussolution

7.75

7.53

7.36

water solubility [mg/L]

1.    determination

2.    determination

 

average

 

7.672

7.719

 

7.696

 

7.377

7.407

 

7.392

 

7.797

7.786

 

87.792

total average

7.626 mg/L

rel. standard deviation

2.5 %

 

Average of 9 test solutions (to 2 significan figures)

water solubility: 7.9 mg/L

rel. standard deviation: 3.5 %

Conclusions:
The water solubility of the test substance was determined to be 7.9 mg/L in water at 25 °C.
Executive summary:

This study was performed by applying the flask method combined with HPLC in accordance with OECD TG 105, EC method A.6 and the US Federal Register 40 CFR part 796.1840 and in compliance with GLP. The solubility of the test substance in water was determined to be 7.9 mg/L at 25 °C.

Description of key information

7.9 mg/L in water at 25 °C, OECD TG 105, flask method, Stulz 1993.

Key value for chemical safety assessment

Water solubility:
7.9 mg/L
at the temperature of:
25 °C

Additional information