Registration Dossier
Registration Dossier
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EC number: 201-126-0 | CAS number: 78-59-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other: thesis
- Title:
- Contribution a l'etude analytique toxicologique et biochimique de l'isophorone.
- Author:
- Dutertre-Catella H
- Year:
- 1 976
- Bibliographic source:
- Universite Rene Descartes, Paris
- Reference Type:
- other: OECD SIDS
- Title:
- 3,5,5-Trimethylcyclohex-2-enone (Isophorone), CAS No. 78-59-1
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 16
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The distribution of isophorone in the organism was studied after ingestion.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,5,5-trimethylcyclohex-2-enone
- EC Number:
- 201-126-0
- EC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Cas Number:
- 78-59-1
- Molecular formula:
- C9H14O
- IUPAC Name:
- 3,5,5-trimethylcyclohex-2-enone
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Dose / conc.:
- 4 000 other: mg/kg bw
- No. of animals per sex per dose / concentration:
- 1
- Control animals:
- not specified
- Details on study design:
- Blood sample determination (0.5 hours after ingestion). Extraction of organs and GC analysis (identification of isophorone via Kovats index).
Results and discussion
Main ADME results
- Type:
- distribution
- Results:
- Distribution of isophorone in organs from high to low amounts: Stomach > ovaries > adrenal > spleen, liver > kidney, brain, heart > lung
Any other information on results incl. tables
MORTALITY
4000 mg/kg:
1/1 female rabbits: 1 hour after ingestion.
CONCLUSION
Rapid diffusion and distribution of isophorone through the body.
No bioaccumulation.
Applicant's summary and conclusion
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