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EC number: 250-528-2 | CAS number: 31242-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 July 2014-07 October 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- (2004)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Version / remarks:
- (2008)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples for analysis were taken immediately after preparation (t=0), after 2.4 hours and after 5 days. The samples taken at t=2.4h and at t=5 days were cooled to room temperature using running tap water.
- Buffers:
- - Acetate buffer pH 4, 0.01 M: aqueous solution of 16.7% 0.01 M sodium acetate and 83.3% 0.01 M acetic acid.
- Phosphate buffer pH 7, 0.01 M: aqueous solution of 0.01 M potassium di-hydrogenphosphate adjusted to pH 7 using 1 N sodium hydroxide.
- Borate buffer pH 9, 0.01 M: aqueous solution of 0.01 M boric acid and 0.01 M potassium chloride adjusted to pH 9 using 1 N sodium hydroxide.
- The buffers contain 0.0009% (w/v) sodium azide. - Details on test conditions:
- - Tier 1 (preliminary) test was performed at pH 4, 7 and 9 at 49.9 ± 0.1°C and the target initial concentration was 10 µg/L.
- The buffer solutions were filter-sterilised through a 0.2 µm filter and transferred into sterile vessels.
- To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes.
- Spiking solution: 100 mg/L of test substance in tetrahydrofuran.
- Test substance was spiked to the test solutions to obtain the target concentration. Spiking volume: 10 µL.
- The spiking volume was < 1% of the sample volume. Nominal concentrations were not corrected for the spiking volume.
- For each sampling time, duplicate sterile vessels under vacuum were filled with 6 mL test solution and placed in the dark in a temperature controlled environment.
- The pH of the test solutions was determined at each sampling time. Actual pH : 4.1, 7.1 and 9.0.
- Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analysed at t=0. No test substance was detected in the blank buffer solutions. - Duration:
- 5 d
- pH:
- 4.1
- Temp.:
- 50 °C
- Initial conc. measured:
- 8.01 - 8.86 µg/L
- Duration:
- 5 d
- pH:
- 7.1
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.51 - 9.79 µg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.47 - 9.8 µg/L
- Number of replicates:
- Two
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- At pH 4, 7 and pH 9, a significant decrease in concentration during the test period was measured (see table below).
- Test performance:
- RECOVERIES
- The recovery in the table below is the mean of duplicate test samples.
- Recovery is the concentration analysed for the test sample at t=0 relative to the nominal concentration.
- The mean recoveries at pH 4, pH 7 and pH 9 fell within the acceptable range of 70-110%. - Transformation products:
- not measured
- % Recovery:
- 84
- pH:
- 4
- Temp.:
- 50 °C
- % Recovery:
- 97
- pH:
- 7
- Temp.:
- 50 °C
- % Recovery:
- 96
- pH:
- 9
- Temp.:
- 50 °C
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the Tier 1 results and the low water solubility of the substance, it was concluded that it is technically not possible to perform the hydrolysis study for this substance. Due to the absence of hydrolysable groups it could be concluded that hydrolysis is not likely for the substance.
- Executive summary:
The preliminary (Tier 1) test of the hydrolysis study as outlined in EC C.7, OECD 111 and OPPTS 835.2120 guidelines was performed at pH 4, 7 and 9 and at 50°C (GLP-compliant study). A significant decrease in concentration ( = 79%) was measured after the 5 -day test period. However, non-linear relationships were obtained indicating that hydrolysis - if any - is not the only process causing the concentration decrease. The substance does not contain hydrolysable functional groups. It was therefore assumed that absorption and/or precipitation are significantly contributing to the observed concentration decrease. Testing at higher concentrations (to lower the influence of adsorption) is not possible due to the limited solubility of the substance in aqueous solutions. Testing at lower concentration (to prevent possible precipitation) is not possible either because it will not be possible to measure such a low concentrations (the limit of quantification of the analytical method is 1 µg/L).
Reference
Tier 1 results of the substance at pH 4, pH 7 and pH 9 at 49.9 ±1 °C
pH code |
Sampling time |
Analysed concentration |
Degree of hydrolysis |
Absolute difference [%] 2.4 hours versus 5 days |
Actual pH |
|
Individual |
Mean |
|||||
|
|
|
|
|
|
|
pH 4 |
0 hours |
8.01/8.86 |
|
|
|
4.1/4.1 |
|
2.4 hours |
2.03/1.92 |
76/77 |
77 |
|
4.1/4.1 |
|
5 days |
1.48/1.21 |
82/86 |
84 |
7.4 |
4.1/4.1 |
|
|
|
|
|
|
|
pH 7 |
0 hours |
9.51/9.79 |
|
|
|
7.1/7.1 |
|
2.4 hours |
2.68/3.62 |
72/62 |
67 |
|
7.1/7.1 |
|
5 days |
2.01/1.50 |
79/84 |
82 |
14 |
7.1/7.1 |
|
|
|
|
|
|
|
pH 9 |
0 hours |
9.47/9.80 |
|
|
|
9.0/9.0 |
|
2.4 hours |
4.14/4.01 |
57/58 |
58 |
|
9.0/9.0 |
|
5 days |
2.03/7.921 |
79 |
79 |
21 |
9.0/9.0 |
1 Outlier; not used for calculations.
Description of key information
As per the conclusions in the source study, the magnesium alkylbenzene sulphonate does not have any hydrolysable functional groups. The registration substance differs only in the length of the alkyl chain, therefore it can be conlcuded that it doesn't contain any hyrdolysable functional groups.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.