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EC number: 291-768-8 | CAS number: 90480-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.02.-16.03.1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-Octadienal, 3,7-dimethyl-, acid-isomerized
- EC Number:
- 291-768-8
- EC Name:
- 2,6-Octadienal, 3,7-dimethyl-, acid-isomerized
- Cas Number:
- 90480-35-6
- IUPAC Name:
- 1-methyl-4-(propan-2-yl)benzene; ethanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4 - 6 weeks
- Weight at study initiation: 87 - 150g for males and 86 - 136g for females
- Fasting period before study: overnight
- Housing: 5 in polypropylene cages with sawdust bedding.
- Diet: ad libitum; standard laboratory rodent diet (Rat and Mouse Expanded Diet No. 1, supplied by Special Diet Services Ltd., Witham, Essex)
- Water: ad libitum; tap water
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.5 +/- 3.5
- Humidity (%): 45 - 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Dose volume: 5.62 mL/kg
- Gavage: metal cannula attached to a graduated syring
- Dose perparation: calculated according to animals bodyweight at the time of dosing - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- RANGE FINDING STUDY
- goal: establish dosing regimen
- animals: 2 male and 2 female
- dose: 5000 mg/kg
- dose volume: 5.62 mL/kg
- observation: daily
- duration: 5 days or until all evidence of toxicity had subsided, whichever was the longer
MAIN STUDY
- Duration of observation period following administration: 14 days
- Frequency of observations: 0.5, 1, 2, 3, 4 and 5 hours after dosing and once daily
- Weighing: days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic post mortem examination
Results and discussion
- Preliminary study:
- No animals died in the Range Finding Study. A dose level of 5000 mg/kg was selected for the Main Study.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3 animals died during the course of the study: 1 male and 1 female on day 1 and another male on day 2
- Clinical signs:
- other: Signs of reaction to treatment observed shortly after dosing in all treated rats included pilo-erection, and abnormal body carriage (hunched posture), lethargy, a decreased respiratory rate and ptosis. A comatose-like condition was observed in one male ra
- Gross pathology:
- Mortalities occurred within one to two days of dosing. Necropsy revealed distension and haemorrhage of the stomach.
Necropsy of the survivors at termination of the study did not reveal any macroscopic abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item is > 5000 mg/kg bw. The substance is not acute toxic and should not be classified.
- Executive summary:
In the current study the oral acute toxicity of the test item was assessed in an OECD 401 study. The study was according to GLP.
5 male and 5 female rats were given 5000 mg/kg bw once and were observed for 14 days. The dose was determined in a range finding study with 2 males and 2 females. No animals died in the range finding study.
In the main study 3 animals died during the study. Necropsy of the animals that died during the study revealed distension and haemorrhage of the stomach. Slightly depressed bodyweight gains were recorded for surviving male rats during the first week of observation. Bodyweight gains of the remaining rats were within normal range throughout the two-week observation period.
Clinical signs observed shortly after dosing in all treated rats included pilo-erection, hunched posture, lethargy, a decreased respiratory rate and ptosis. A comatose-like condition was observed in one male rat prior to death and wet fur was seen in two males. Recovery of the survivors, as judged by external appearance and behaviour, was complete by day 6. Necropsy of the survivors at termination of the study did not reveal any macroscopic abnormalities.
Based on these observations the LD50 is > 5000 mg/kg bw. The substance is not acute toxic and should not be classified.
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