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EC number: 291-768-8 | CAS number: 90480-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Remarks:
- Human Repeat Insult Patch Test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 18.01.-26.02.1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
- Type of sensitisation studied:
- skin
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Shelanski/Shelanski method (Ref: Shelanski H A and Shelanski M V 1953. A New Technique of Human Patch Tests, Proc Sci Section Toil Group Assoc 19).
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,6-Octadienal, 3,7-dimethyl-, acid-isomerized
- EC Number:
- 291-768-8
- EC Name:
- 2,6-Octadienal, 3,7-dimethyl-, acid-isomerized
- Cas Number:
- 90480-35-6
- IUPAC Name:
- 1-methyl-4-(propan-2-yl)benzene; ethanol
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Age: 21 - 65+
- Females: 72
- Males: 20
Remark: All subjects were required to complete a questionnaire before the start of the test, and to read and sign an informed consent form. - Clinical history:
- not specified
- Route of administration:
- dermal
- Details on study design:
- A. INDUCTION EXPOSURE
- No. of exposures: 9
- Exposure period: 3 weeks
- Test groups: 92 volunteers
- Control group: no
- Site: 2 x 2 cm
- Frequency of applications: 3 x per week (Monday, Wednesday and Friday)
- Duration: 24h
- Concentrations: 0.3 ml of 10% in DEP/EtOH 1:1,
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 14 days later
- Test groups: 92 volunteers
- Control group: no
- Site: 2 x 2 cm
- Concentrations: 10%
- Evaluation (hr after challenge): 48 and 96
Results and discussion
- Results of examinations:
- Ninety two volunteers started in the test. Nine volunteers dropped out during induction due to different reasons not related to adverse effects of the test item.
Very little irritation was recorded during induction.
At challenge, the test item did not produce reactions indicative of skin sensitisation.
Applicant's summary and conclusion
- Conclusions:
- The test item did not produce reactions indicative of skin sensitisation.
- Executive summary:
In the current study the skin sensitising potential of the test item was assessed in a Human Repeat Insult
Patch Test was carried out with 92 volunteersover the age of 18 years. Important to mention is that 3
other fragrances were tested at the same time, but the results are reported seperately.
The test item was applied at a concentration of 10% in DEP/EtOH both during the induction and
challenge phase.
The volunteers received 9 topical inductions and after a rest period of 14 days, they were challenged.
Challenges were read 48 and 92 hours later.
During the induction phase 9 volunteers dropped out because of various reasons not related to adverse effects of the test item.
Therefore a total of 81 volunteers completed the test.
Low levels of irritation were recorded during induction and at challenge no reactions indicative of skin sensitisation were recorded.
It is concluded from the test results that test item did not elicit reactions indicative of skin sensitisation under the test conditions.
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