Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-372-6 | CAS number: 58-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 05 July 2017. Experimental completion date: 23 August 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).
- Deviations:
- no
- Principles of method if other than guideline:
- The determination was carried out using a procedure designed to be compatible with European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Menadione
- EC Number:
- 200-372-6
- EC Name:
- Menadione
- Cas Number:
- 58-27-5
- Molecular formula:
- C11H8O2
- IUPAC Name:
- 2-methyl-1,4-dihydronaphthalene-1,4-dione
Constituent 1
- Specific details on test material used for the study:
- Identification: Beta-Menadione
CAS No: 58-27-5
Description: light yellow powder
Batch number: J16090701
Purity: 99.2%
Expiry date: 06 September 2017
Storage conditions: room temperature, in the dark
Results and discussion
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 10 µm
- Distribution:
- >= 0.452 - <= 0.869 %
- No.:
- #2
- Size:
- < 5.5 µm
- Distribution:
- >= 0.046 - <= 0.12 %
- No.:
- #3
- Size:
- < 2.4 µm
- Distribution:
- >= 0.003 - <= 0.045 %
- No.:
- #4
- Size:
- < 1.61 µm
- Distribution:
- >= 0 - <= 0.003 %
- No.:
- #5
- Size:
- < 0.307 µm
- Distribution:
- >= 0 - <= 0.003 %
Any other information on results incl. tables
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement | Result |
Mass of test item transferred to sieve (W1) | 14.75 g |
Mass of test item passed through sieve (W3 – W2) | 8.35 g |
Percentage of test item less than 100 μm | 56.60% |
Cascade Impactor
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle Size Cut Points (μm) |
Cumulative Mass (g) | Cumulative Percentage (%) | ||||
Determination 1 | Determination 2 | Determination 3 | Determination 1 | Determination 2 | Determination 3 | |
<10.0 | 0.0189 | 0.026 | 0.0138 | 0.611 | 0.869 | 0.452 |
<5.5 | 0.0037 | 0.0021 | 0.0014 | 0.12 | 0.07 | 0.046 |
<2.4 | 0.0014 | 0.0001 | 0.0002 | 0.045 | 0.003 | 0.007 |
<1.61 | 0.0001 | 0 | 0 | 0.003 | 0 | 0 |
<0.307 | 0.0001 | 0 | 0 | 0.003 | 0 | 0 |
Mean cumulative percentage with a particle size less than 10.0 μm : 0.644% Mean cumulative percentage with a particle size less than 5.5 μm : 0.079%
Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 10 minutes then sampled from the top, middle and bottom.
Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Applicant's summary and conclusion
- Conclusions:
- Particle size data acquired for the test item is:
Percentage of test item with an inhalable particle size <100 μm: 56.6 % (Sieve Method)
Percentage of test item with a thoracic particle size <10.0 μm: 0.644 % (Cascade impactor method)
Percentage of test item with a respirable particle size <5.5 μm: 0.079 % (Cascade impactor method) - Executive summary:
Particle Size Distribution.. Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002). The results are as follows:
Measurement Method Result Proportion of test item having an inhalable particle size <100 μm Sieve 56.60% Proportion of test item having a thoracic particle size <10.0 μm Cascade Impactor 0.64% Proportion of test item having a respirable particle size <5.5 μm Cascade Impactor 0.08%
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.