Rectified Essential Oil of Pogostemon cablin (Lamiaceae) with high content in alpha and delta guaiene obtained from leaves by distillation.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08-09 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method. Test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 15 and 16 November 2017/ Signed on 15 May 2018

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

255.5 °C

Atm. press.:

>= 98 919 - <= 99 018 Pa

Decomposition:

yes

Pre-test boiling point:

All observations are presented in the following table.

Observations	Temperatures in °C
Individual bubble visible	Since 73.1
Bubbles rose faster	Since 257.6
Bubbles rose consecutively faster	277
Bubble chain, turned off gas burner	310
The chain broke	294.5
Optically unchanged	After cooling down

Main test Siwoloboff Method:

Observations and measured values are presented in the following table.

Observations	First Determination Atmospheric pressure 99018 Pa	Second Determination Atmospheric pressure 98919 Pa
When the sample tube was set into the aluminium block, individual bubble was visible	245.0 °C	245.0 °C
more bubble visible	Since 248°C	Since 248°C
Bubble chain, turned off gas burner, colour was yellow	276.2 °C	274.5 °C
The chain broke	255.0 °C	256.0 °C
The test item stay yellow instead of pale yellow (original colour) ,see photo	After cooling down

Since boiling under decomposition was observed, the result is stated without Sidney-Young correction.

The colour change during determination confirms the decomposition.

Therefore boiling point under decomposition of the test item should be stated as 255.5 ± 0.7 °C (528.7 ± 0.7 K).

Conclusions:

The determination of boiling point of the test item was determined with the Siwoloboff method. The test item had changed its colour from pale yellow to yellow during the tests. Therefore, the boiling point should be stated as 255.5 ± 0.7 °C (corresponding to 528.7 ± 0.7 K) under decomposition. This values is the mean of two independent determinations. As the test item decomposed, a correction to standard pressure following Sidney-Young was not applied.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp EU A.2 guideline.

The determination of boiling point of the test item was determined with the Siwoloboff method. The test item had changed its colour from pale yellow to yellow during the tests. Therefore, the boiling point should be stated as 255.5 ± 0.7 °C (corresponding to 528.7 ± 0.7 K) under decomposition. This values is the mean of two independent determinations. As the test item decomposed, a correction to standard pressure following Sidney-Young was not applied.

Description of key information

The boiling point of test item should be stated as: 255.5± 0.7 °C (528.7 ± 0.7 K) under decomposition of the test item.

This value is the mean of two independent determinations without Sydney-Young correction.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

255.5 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/ EU A2 guideline is available.

It is considered as a key study, and the result is retained as key data.