Registration Dossier
Registration Dossier
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EC number: 276-012-7 | CAS number: 71786-55-5
Endpoint summary
Administrative data
Description of key information
LD50 > 5000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The study was carried out in accordance with OECD Guideline No. 401, "Acute Oral Toxicity".
The substance was administered by oral gavage, to five rats of each sex, at 5000 mg/kg body weight. Macroscopic examination was performed at the end of the experìmental period. Apart from pìloerection, and dark blue urine and faeces noted, no signs of ill health or behaviour changes were seen during the observation period. Macroscopic post mortem examination of the surviving animals at termination revealed greenish discolouration of the glandular stomach, intestines and mesenterial lymph nodes, dark red / black coloured kidneys in all animals, and thickening of the limiting ridge and greenish discolouration of the testes in a few ani ma'ls. The oral LD50 value in rats of either sex was established as exceeding 5000 mg/kg body weight.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), 3.1 Acute toxicity section, substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to the numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
The oral LD50 value was established to be greater than 2000 mg/kg body weight, therefore test substance is out of the classification limit for acute oral toxicity (oral acute toxicity category 4: 300 < ATE ≤ 2000 mg/kg bw).
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