Registration Dossier
Registration Dossier
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EC number: 690-928-8 | CAS number: 39992-90-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
The study is not necessary based on the expert statement attached to study record.
Key value for chemical safety assessment
Additional information
To avoid animal testing all available data should be evaluated and alternative methods like QSAR should be used to fulfil the REACH endpoint requirements. Thus, QSAR was used to fulfil the REACH endpoint requirements for endpoint 9.1.3 (short-term toxicity to fish).
Calculations have been performed using several software tools. The calculated results clearly indicate that fish is less sensitive to IPDI-Uron in comparison to daphnia and algae (for details see expert statement attached).
In addition to the calculations, experimental results are available on the acute toxicity to daphnia and algae. In both species, no effects were seen up to the limit concentration of 100 mg/L. As QSAR calculated results for all three species indicate fish as being the least sensitive, lethal effects at a limit concentration of 100 mg/L are not expected in fish if an experimental test according to OECD guideline 203 was performed. Therefore, and under consideration of animal welfare reasons, an additional study on the acute toxicity to fish is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
