Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-293-0 | CAS number: 2706-28-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed jornal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Absorption, Metabolism and Excretion of the Sulphonated Azo Dye, Acid Yellow, by Rats
- Author:
- Ronald R. Scheline and Britt Longberg
- Year:
- 1 965
- Bibliographic source:
- Acta pharmacol. el toxicol. 1965, 23, 1-14
- Reference Type:
- secondary source
- Title:
- Information P·roflles on Potential Occupational Hazards: Aminoazobenzenes
- Author:
- National Institute for Occupational Safety and Health
- Year:
- 1 981
- Bibliographic source:
- U.S. DEPARTMENT OF COMMERCE NATIONAL TECHNICAL INFORMATION SERVICE, November 1981, 1-116
Materials and methods
- Objective of study:
- other: Absorption, Metabolism and Excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Absorption, Metabolism and Excretion of Acid Yellow in rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate
- EC Number:
- 220-293-0
- EC Name:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate
- Cas Number:
- 2706-28-7
- Molecular formula:
- C12H11N3O6S2.2Na
- IUPAC Name:
- disodium 2-amino-5-[(4-sulfonatophenyl)diazenyl]benzenesulfonate
- Reference substance name:
- Acid Yellow
- IUPAC Name:
- Acid Yellow
- Details on test material:
- - Name of test material (as cited in study report): Acid Yellow
- Molecular formula (if other than submission substance): C12H11N3O6S2.2Na
- Molecular weight (if other than submission substance): 401.3301 g/mole
- Substance type: Organic
- Physical state: Solid
- Impurities (identity and concentrations): 34 %
Constituent 1
Constituent 2
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 250 to 350 g
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):water , ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 100 mg
- Amount of vehicle (if gavage): 1 ml - Duration and frequency of treatment / exposure:
- 3 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg -oral
2 mg- intraperitoneal
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- not specified
- Positive control reference chemical:
- No data
- Details on study design:
- No data
- Details on dosing and sampling:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary studies:
- No data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Total gastrointestinal absorption was observed in rat by oral route
- Details on distribution in tissues:
- No data
- Details on excretion:
- Only 2.6, 0.0, and 0 .1.2S. of the unchanged compound appeared in the urine, feces, and bile, respeot1vely and 87% intraperitoneal amount found in the urine. prolonged excretion in bile. Total 1.1 % was excreted in urine.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate was metabolite in the form of N-acetylsulphanilic acid and 5-acetylamino- 2-aminobenzene sulphonic acid conjugate respectively.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Acid Yellow was considered to be have Low bio-accumulation potential in rats based on study results. - Executive summary:
Upon oral administration, Acid Yellow were totally absorbed by gastrointestinal trak, metabolite in the form of N-acetylsulphanilic acid and 5-acetylamino- 2-aminobenzene sulphonic acid conjugaterespectively. only 2.6, 0.0, and 0 .1.2S. of the unchanged compound appeared in the urine, feces, and bile, respeot1vely and 87% intraperitoneal amount found in the urine. prolonged excretion in bile. Total 1.1 % was excreted in urine at 24 hours and not identified after 42 hours. Theefore Acid Yellow was considered to be have Low bio-accumulation potential in rats based on study results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
