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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 February - 02 June 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
GLP compliance:
yes (incl. certificate)
Remarks:
The Department of Health of the Government of the United Kingdom
Type of distribution:
volumetric distribution

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Benzene, 1,1 ‘-(1 ‚2-ethanediyl)bis-, brominated, [CAS No. 109283440-6]
- Substance type: white powder
- Physical state: solid
- Analytical purity: no data
- Lot/batch No.: 20090105
- Storage condition of test material: room temperature in the dark

Results and discussion

Particle size
Percentile:
D50
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Any other information on results incl. tables

The overall cumulative amounts of test material with a particle size less than 10.0 pm (%) from determinations 1 to 3 are shown in the following table:

 

Determination

Cumulative Amount of Test Material Less Than 10.0 pm (%)

Mean Cumulative Amount of Test Material Less Than 10.0 pm (%)

1

1.88

0.926

2

0.330

3

0.564

 

The overall cumulative amounts of test material with a particle size less than 5.5 pm (%) from determinations 1 to 3 are shown in the following table:

 

Determination

Cumulative Amount of Test Material less than 5.5 pm (%)

Mean Cumulative Amount of Test Material less than 5.5 um (%)

1

0.447

0.263

2

0.110

3

0.232

 

Too few particles were of a size less than 10.0 pm to allow accurate assessment of mass median aerodynamic diameter.

Particle size data acquired for the test material are shown in the following table:

Measurement

Method

Result

Proportion of test material having an inhalable particle size less than 100 pm

Sieve

19.1 %

Proportion of test material having a thoracic particle size less than 10.0 pm

Cascade impactor

0.926 %

Proportion of test material having a respirable particle size less than 5.5 pm

Cascade impactor

0.263%

Applicant's summary and conclusion

Conclusions:
Proportion of test material having an inhalable particle size less than 100 µm: 19.1% (sieve method)
Proportion of test material having a thoracic particle size less than 10 µm: 0.926% (cascade impactor)
Proportion of test material having a respirable particle size less than 5.5 µm: 0.263% (cascade impactor)