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EC number: 220-266-3 | CAS number: 2695-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-28 October 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Test sample, suspended in an appropriate solvent was dosed to test animals by oral gavage. The LD50 was determined according to the Litchfield-Wilcoxon method method. Test procedure is consistent with the requirements of the OECD 401 method.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 4-vinylbenzenesulphonate
- EC Number:
- 220-266-3
- EC Name:
- Sodium 4-vinylbenzenesulphonate
- Cas Number:
- 2695-37-6
- Molecular formula:
- C8H8O3S.Na
- IUPAC Name:
- .
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICL-ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The mice were kept in the animal room, where temperature was controlled at 22±0.5 oC and its relative humidity was controlled 60±5%. The mice took solid feed CE-2 (CLEA Japan) and drank tap water ab libium
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Since sodium p-styrenesulfonate was solid, the test substance was suspended into olive oil to prepare 40 %(w/v) slurry and used for the test.
- Doses:
- The applied doses were set at 16.00, 13.92, 12.10, 10.52 and 9.14 g/kg
- No. of animals per sex per dose:
- 10 male animals per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 6 400 mg/kg bw
- Based on:
- test mat.
- Remarks:
- A purity correction has been applied to correct for the vehicle content.
- Mortality:
- Tests were conducted at technically maximum dose levels, 16.00, 13.92, 12.10, 10.52 and 9.14 g/kg at 40% in olive oil, but no mortality of the test animal was observed at any dose levels.
- Clinical signs:
- Decrease of spontaneous motion and piloerection were observed after treatment, but the symptoms were disappeared in the next day. Dose groups at 16.00, 13.92 and 12.10 g/kg, light diarrhea were observed.
- Gross pathology:
- At necropsy at the end of test, sodium p-styrenesulfonate treatment group gave no obvious change observations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Assigning a correction for the content of vehicle, the LD50 of the substance is >6400 mg/kg
- Executive summary:
The acute oral toxicity of the substance has been assessed following dosing of male ICR-SLC mice at dose levels upto 16 g/kg with a dose concentration of 40% in olive oil. Correcting for vehicle content, the maximum dose was 6400 mg/kg of test substance. Dosing was conducted by oral gavage using a test method consistent with the classification OECD 401 style of acute oral toxicity testing, but not in compliance with GLP. No mortality was observed upto the maximum dose. The LD50 >6400mg/kg.
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