Registration Dossier
Registration Dossier
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EC number: 203-721-0 | CAS number: 109-94-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Data available in the present report on absorption, metabolism and excretion of the chemical ethyl formate and the metabolites formic acid, & ethanol & ethanol being metabolised further in the liver to acetaldehyde, acetic acid, and, finally, CO2 indicate that overloading of the buffer capacity of the body and subsequently, a metabolic acidosis is not expected. Also, from the reported elimination rates of ethanol it can be seen that accumulation of metabolites will not occur. Thus the chemical is likely to exhibit low bio-accumulation potential based on data reported.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Absorption: Ethyl formate is readily absorbed into the blood via the alveoli of the respiratory system. It is also reported to be absorbed from the gastrointestinal tract and slightly through the skin.
Distribution: Distributed to the liver where it is metabolized.
Metaboliosm: Enzymatic hydrolysis occurs. With moisture, ethyl formate readily hydrolyses into formic acid and ethanol. Formic acid is metabolised further by the tetrahydrofolate system to CO2. Ethanol is metabolised further in the liver to acetaldehyde, acetic acid, and, finally, CO2, by alcohol dehydrogenase, aldehyde dehydrogenase, and the tricarbonic acid cycle, respectively.
Excretion: For ethanol, the elimination rates are 1.15 and 1.35 mmol/kg bw/hour in women and men, respectively. From these figures, it can be seen that accumulation of metabolites will not occur.
From the above, it can be concluded thatthe chemical is likely to exhibit low bio-accumulation potential.
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