Registration Dossier
Registration Dossier
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EC number: 204-289-6 | CAS number: 118-96-7
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Toxicity experiments were conducted following U.S. Environmental Protection Agency guidance 1994. Methods for measuring the toxicity of sediment-associated contaminants with estuarine and marine amphipods. EPA 600/R-94/025. Narragansett, RI
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4,6-trinitrotoluene
- EC Number:
- 204-289-6
- EC Name:
- 2,4,6-trinitrotoluene
- Cas Number:
- 118-96-7
- Molecular formula:
- C7H5N3O6
- IUPAC Name:
- 2-methyl-1,3,5-trinitrobenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
The TNT spiked into sediment degraded to aminated transformation products during mixing and also during the sediment exposure. Different patterns of TNT degradation were observed for the two sediments. Although TNT comprised the largest fraction of HPLC-identified compounds during the experimentin YB sediment, aminated transformation products were the dominating compounds in extracts collected for most treatments of the SDB sediment. The extent of TNT degradation decreased with increasing spiking concentration at all sampling times for SDB sediments, and a similar trend clearly was observed for the day 10 samples from YB sediments.
TNT was not observed in any of the tissue extract. The compounds 2 -ADNT and 4 -ADNT were the only degradation products quantified in tissue extracts, with 4 -ADNT representing 83 and 72% of the total for YB and SDB sediment-exposed amphipods an avarage, respectively.This is consistent withthe increased presence of 4 -ADNT abserved in the sediments.
The apparent preferential metabolism of TNT to 4 -ADNT over that to 2 -ADNT has been observed previously in other animals.
Applicant's summary and conclusion
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