Registration Dossier
Registration Dossier
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EC number: 204-289-6 | CAS number: 118-96-7
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation: terrestrial
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Test organisms (species):
- other: Eisenia andrei
- Total exposure / uptake duration:
- ca. 14 d
- Type:
- BCF
- Value:
- ca. 5 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 14 d
- Calculation basis:
- steady state
- Conclusions:
- Although the biotransformation of TNT to its reduced amine products, 2-ADNT and 4-ADNT occurs in soil within 14 d, these compounds show little further transformation. Following a 14-d exposure to TNT-amended soil, only TNT metabolites were detected in earthworms; however, the final TNT concentrations in the soil were only 1.5–2.5% of initial measured levels when earthworms were sampled. Exposure of earthworms to 2-ADNT and 4-ADNT-amended soil did not lead to extensive transformation in the earthworms. Instead, the compounds appeared to bioaccumulate. In contrast to what is known in other species, the biotransformation of TNT to 4-ADNT in the earthworm does not represent an effective detoxification process. TNT BCF: ca. 5.0 L/kg
Reference
The calculation of a 14 -d BCF for TNT is difficult because this compound degrades to undetectable levels in earthworm tissues. However, the apparent BCF that could be calculated from the sum of recovered TNT metabolites in soil and in earthworm tissues after 14-d (5.0 +/- 0.1) is comparable to the values observed for 2 -ADNT and 4 -ADNT.
Description of key information
The calculation of a 14 -d BCF for TNT is difficult because this compound degrades to undetectable levels in earthworm tissues. However, the apparent BCF that could be calculated from the sum of recovered TNT metabolites in soil and in earthworm tissues after 14-d (5.0 +/- 0.1) is comparable to the values observed for 2 -ADNT and 4 -ADNT.
Key value for chemical safety assessment
- BCF (terrestrial species):
- 5 L/kg ww
Additional information
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