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Diss Factsheets
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EC number: 215-607-8 | CAS number: 1333-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reporting (study summary only) of a guideline-comparable study.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chromic acid
- EC Number:
- 231-801-5
- EC Name:
- Chromic acid
- Cas Number:
- 7738-94-5
- Molecular formula:
- CrH2O4
- IUPAC Name:
- dihydroxy(dioxo)chromium
- Details on test material:
- Test material name: chromic acid
No further details reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No further details reported
- Doses:
- 0, 32, 40, 50, 63, 80 & 100 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 52 mg/kg bw
- 95% CL:
- >= 42 - <= 62
- Mortality:
- Deaths occurred at 32 mg/kg bw (1M, 2F), 40 mg/kg bw (1M), 50 mg/kg bw (2M, 3F), 63 mg/kg bw (3M, 4F), 80 mg/kg bw (3M, 4F) and 100 mg/kg bw (5M, 5F), within three days of dosing.
- Clinical signs:
- other: Lacrimation, hunched posture, hypoactivity, soft/reduced faeces, anogenital staining, red/brown facial staining.
- Gross pathology:
- Findings were apparent in the stomach, intestines, brain, kidney and lungs in decedent animals in all groups, but may have been secondary effects. No effects of treatment were apparent in animals surviving to scheduled necropsy.
- Other findings:
- Slightly increased liver weights
Any other information on results incl. tables
The report indicates that the primary cause of death was gastrointestinal corrosion, rather than systemic toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- other: Toxic if swallowed based on EU GHS criteria
- Conclusions:
- The acute oral LD50 of chromic acid was found to be 52 (42-62) mg/kg bw in the rat. Chromic acid is classified as 'Toxic if swallowed', based on the results of this study.
- Executive summary:
Fischer 344 rats (5/sex/group) were gavaged with a single dose of chromic acid at dose levels of 0, 32, 40, 50, 63, 80 or 100 mg/kg bw and observed for 14 days. Deaths occurred in all dose groups, within 3 days of dosing. Reduced weight gain or initial weight loss was apparent in all groups. Gross necropsy of decedents revealed corrosive effects on the gastrointestinal tract. The acute oral LD50 of chromic acid in the rat was found to be 52 (42-62) mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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