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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report that meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Pharmacological studies on Ca meso-tartrate I. Acute and subacute toxicity tests
Author:
Akatsuka, K., Hashimoto, T. and Takeuchi, K.
Year:
1977
Bibliographic source:
Ouyou-Yakuri, 14, 963-975. (in Japanese)

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium chloride
EC Number:
233-140-8
EC Name:
Calcium chloride
Cas Number:
10043-52-4
Molecular formula:
CaCl2
IUPAC Name:
calcium dichloride

Test animals

Species:
mouse
Strain:
ICR
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 5 % Arabic gum in water
No. of animals per sex per dose:
15

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
402 mg/kg bw

Applicant's summary and conclusion