Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 233-140-8 | CAS number: 10043-52-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Ganong`s Review of Medical Physiology
- Author:
- Barrett KE et al.
- Year:
- 2 016
- Bibliographic source:
- McGraw-Hill Education
Materials and methods
Test material
- Reference substance name:
- Calcium chloride
- EC Number:
- 233-140-8
- EC Name:
- Calcium chloride
- Cas Number:
- 10043-52-4
- Molecular formula:
- CaCl2
- IUPAC Name:
- calcium dichloride
Constituent 1
Results and discussion
- Preliminary studies:
- Calcium chloride is easily dissociated into calcium and chloride ions in water. The absorption, the distribution and the excretion of the ions in animals and humans are regulated separately. Calcium and chloride are essential constituents of the body of all animal species including humans. Calcium is essential for the formation of skeletons and the regulation of neural transmission, muscle contraction and coagulation of the blood. Chloride is required for regulating intracellular osmotic pressure and buffering. The homeostasis and mechanisms of action of calcium and chloride ions are extensively reviewed in textbooks on pharmacology, physiology, biochemistry and nutritional science.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
