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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined; no data on purity of test sample; no data on no.of animals used.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Method: 100 µl, eye, observation period: 7 days
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 7 d
Score:
ca. 0
Max. score:
110
Reversibility:
other: no effects observed
Remarks on result:
other: In this eye irritation study the test substance was applied to the conjunctival sack of rabbits (no nr.of animals given) in a dose of 100 µl. During the 7 days of observation time no changes of the mucous membrane, iris and cornea could be observed.

Any other information on results incl. tables

Mesamoll was found to be not eye irritating.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In this eye irritation study the test substance was applied to the conjunctival sack of rabbits (no nr.of animals given) in a dose of 100 µl.

During the 7 days of observation time no changes of the mucous membrane, iris and cornea could be observed.

Mesamoll was found to be not eye irritating.

The NOEL therefore is 100 µl.