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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data on purity of test sample, non-GLP
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity in male rats
GLP compliance:
not specified
Test type:
other: Acute oral toxicity in male rats
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: none
Doses:
5.0; 15.0 ml/kg bw.
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 15 mL/kg bw

Any other information on results incl. tables

 Dose (ml/kg bw)  Timepoint of death  Toxicological result (No.of mortalities/ Animals with Symptoms/ No.of animals)

 5.0

 -

0/0/10 

 15.0

 -

 0/10/10

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

The acute oral toxicity of Mesamoll was tested in male Wistar rats treated via gavage with the doses: 5.0 and 15.0 ml/kg bw. The observation period was 14 days. No mortalities could be observed. Signs of intoxication were observed in the 15.0 ml/kg bw dose group (apathy, ruffled fur and diarrhea). The LD 50 was higher than 15 ml/kg bw (corresponds to 15.9 g/kg).