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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline study or GLP defined, no data on purity of test sample, no dose defined, no sex defined.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Method: other: human n=7, saturated patch, right forearm, 24 h exposure, observation period: 7 days
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
human
Strain:
not specified

Test system

Type of coverage:
other: ball of absorbent cotton and adhesive bandage
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
other: no control test persons described
Duration of treatment / exposure:
24 h
Observation period:
7 d
Number of animals:
7 test persons

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: 7 volunteers
Time point:
other: 8 h
Score:
ca. 0
Max. score:
8
Reversibility:
other: no effects observed
Remarks on result:
other: In a study in 7 humans the test substance (no dose defined) was applied to the right forearm and fixed with a ball of absorbent cotton and adhesive bandage for 24 hours. The observation:7d. No skin irritating or corrosive effects could be observed.

Any other information on results incl. tables

No skin irritating or corrosive effects observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a study in 7 humans (no sex defined) the test substance (no dose defined) was applied to the right forearm and fixed with a ball of absorbent cotton and adhesive bandage for 24 hours. The observation period was 7 days. No skin irritating or corrosive effects could be observed.