Butan-1-ol

Repeated dose toxicity: dermal

Administrative data

Endpoint:

short-term repeated dose toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Comparative toxicologic effects of some isobutyl carbinols and ketones

Author:

McOmie W.A., Anderson H.H.

Year:

1949

Bibliographic source:

Anderson H.H. (ed.), The toxicity of dicyclohexylamine nitrite. University of California Press, Berkeley, USA, Volume 2, No. 17, pp. 217-230, 1949

Reference 2

Reference Type:

review article or handbook

Title:

n-Butanol

Author:

ECETOC

Year:

2003

Bibliographic source:

ECETOC JACC No. 41

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Butan-1-ol was applied to rabbit skin and the effects were studied.

GLP compliance:

not specified

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Butan-1-ol

EC Number:

200-751-6

EC Name:

Butan-1-ol

Cas Number:

71-36-3

Molecular formula:

C4H10O

IUPAC Name:

butan-1-ol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on exposure:

The test substance was applied to nonabraded skin.

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

5 h each exposure

Frequency of treatment:

12 times in 21 days

Doses / concentrations

Dose / conc.:

100 other: %

No. of animals per sex per dose:

A total of 2 rabbits was used.

Control animals:

no

Examinations

Observations and examinations performed and frequency:

No details on conducted observations were provided.

Sacrifice and pathology:

GROSS PATHOLOGY: Yes

HISTOPATHOLOGY: Yes

Results and discussion

Results of examinations

Clinical signs:

no effects observed

Dermal irritation:

effects observed, treatment-related

Description (incidence and severity):

Slight erythema was detected. The effect was reversible.

Mortality:

no mortality observed

Body weight and weight changes:

not examined

Food consumption and compound intake (if feeding study):

not examined

Food efficiency:

not examined

Water consumption and compound intake (if drinking water study):

not examined

Ophthalmological findings:

not examined

Haematological findings:

not examined

Clinical biochemistry findings:

not examined

Urinalysis findings:

not examined

Behaviour (functional findings):

not examined

Immunological findings:

not examined

Organ weight findings including organ / body weight ratios:

not examined

Gross pathological findings:

no effects observed

Description (incidence and severity):

No test substance related changes were detected on internal organs.

Neuropathological findings:

not examined

Histopathological findings: non-neoplastic:

effects observed, treatment-related

Description (incidence and severity):

Polymorpghonuclear infiltration in the upper dermis was detected. No keratin sloughing was observed and hair follicles appeard normal.

Histopathological findings: neoplastic:

not examined

Other effects:

not examined

Effect levels

Key result

Dose descriptor:

conc. level:

Effect level:

100 other: %

Based on:

test mat.

Sex:

not specified

Basis for effect level:

dermal irritation

Target system / organ toxicity

Key result

Critical effects observed:

no