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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Sensory response to certain industrial sovent vapours
Author:
Nelson K.W. et al.
Year:
1943
Bibliographic source:
J. Ind. Hyg. and Toxicol. 25, 282-285, 1943

Materials and methods

Endpoint addressed:
skin irritation / corrosion
eye irritation
respiratory irritation
Principles of method if other than guideline:
Sensory limit tests in humans
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butan-1-ol
EC Number:
200-751-6
EC Name:
Butan-1-ol
Cas Number:
71-36-3
Molecular formula:
C4H10O
IUPAC Name:
butan-1-ol
Test material form:
liquid

Results and discussion

Results:
Sensory irritation/Irritation:
<25 ppm =75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm =150 mg/m3: sensory eye irritation (vapor irritated majority of subjects)
25 ppm: sensory nose irritation (vapor irritated majority of subjects)
25 ppm: sensory throat irritation (vapor irritated majority of subjects)

Applicant's summary and conclusion

Conclusions:
Butanol at > 25 ppm caused mild irritation to the eyes, nose and throat.