Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-871-9 | CAS number: 75-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- tests for metabolism and pharmacokinetics propably according or equivalent to OECD 417
- GLP compliance:
- not specified
Test material
- Reference substance name:
- HFA22
- IUPAC Name:
- HFA22
- Reference substance name:
- Chlorodifluoromethane
- EC Number:
- 200-871-9
- EC Name:
- Chlorodifluoromethane
- Cas Number:
- 75-45-6
- Molecular formula:
- CHClF2
- IUPAC Name:
- chlorodifluoromethane
- Details on test material:
- no data
Constituent 1
Constituent 2
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- groups of 3 male humans, no further information
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- not specified
- Details on exposure:
- exposure to vapor concentrations in an inhalation chamber
- Duration and frequency of treatment / exposure:
- 4 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
92 or 518 ppm
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- no data
- Details on dosing and sampling:
- Blood and expired air samples were
taken during exposure and for up to 26 hours after exposure. Urine samples
were taken for up to 22 hours after exposure. - Statistics:
- no data
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The compound was absorbed
very quickly, reaching plateaus of 0.25 and 1.36 ug/ml after approximately
4 and 3 hours of exposure for the low- and high-dose levels, respectively.
End-tidal breath concentrations of the test compound during exposure were
similar to the exposure concentrations, indicating that only a small
proportion of the available dose was absorbed. - Details on distribution in tissues:
- Elimination of the compound
from blood was triphasic, with estimated half-lives of 0.005, 0.20, and 2.7
hours. The first phase probably corresponded to elimination from blood and
rapidly perfused tissues, whereas the second and third phases of
elimination probably corresponded to elimination from slowly perfused
tissues and fat, respectively.
- Details on excretion:
- The parent compound was detected in urine
samples from all subjects; very little fluoride ion was detected in urine
samples.
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- test compound was probably not metabolized to
a significant extent
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: expert judgement
- Executive summary:
In tests for metabolism and pharmacokinetics chlorodifluoromethane) was evaluated in groups of 3 male humans exposed via inhalation to vapor concentrations of 92 or 518 ppm for 4 hours in an inhalation chamber. Blood and expired air samples were taken during exposure and for up to 26 hours after exposure. Urine samples were taken for up to 22 hours after exposure. The compound was absorbed very quickly, reaching plateaus of 0.25 and 1.36 ug/ml after approximately 4 and 3 hours of exposure for the low- and high-dose levels, respectively. End-tidal breath concentrations of the test compound during exposure were similar to the exposure concentrations, indicating that only a small proportion of the available dose was absorbed. Elimination of the compound from blood was triphasic, with estimated half-lives of 0.005, 0.20, and 2.7 hours. The first phase probably corresponded to elimination from blood and rapidly perfused tissues, whereas the second and third phases of elimination probably corresponded to elimination from slowly perfused tissues and fat, respectively. The parent compound was detected in urine samples from all subjects; very little fluoride ion was detected in urine samples, indicating that the test compound was probably not metabolized to a significant extent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)