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Diss Factsheets
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EC number: 200-871-9 | CAS number: 75-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to Regulation (EC) No. 440/2008 Method B.6 - Skin sensitisation - with modification as original method is not applicable to gaseous substances.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- gaseous substance applied by polypropylene capsule
- Principles of method if other than guideline:
- The skin sensitisation potential of chlorodifluoromethane was carried out in guinea pigs using
a technique derived from the Magnusson and Kligman maximisation test (Gonnet and Guillot,
1986).
During the induction period the test compound was applied in liquefied conditions under a polypropylene capsule for 48 at the dose of 0.5 ml. At challenge the test compound was applied in the same condition at the dose of 0.25 ml. No vehicle was used. Macroscopic and histological evaluation of skin reaction was scored up to 48 hours after removal of the occlusive capsule. - GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Chlorodifluoromethane
- EC Number:
- 200-871-9
- EC Name:
- Chlorodifluoromethane
- Cas Number:
- 75-45-6
- Molecular formula:
- CHClF2
- IUPAC Name:
- chlorodifluoromethane
- Details on test material:
- During the induction period the test compound was applied in liquefied conditions under a polypropylene capsule for 48 at the dose of 0.5 ml. At challenge the test compound was applied in the same condition at the dose of 0.25 ml. No vehicle was used.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Information not available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- gaseous subsance applied contained in polypropylene capsule
- Concentration / amount:
- Induction period: 0.5 ml pure substance (100%)
Challenge period: 0.25 ml pure substance (100%)
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- gaseous subsance applied contained in polypropylene capsule
- Concentration / amount:
- Induction period: 0.5 ml pure substance (100%)
Challenge period: 0.25 ml pure substance (100%)
- No. of animals per dose:
- Information not available
- Details on study design:
- Information not available
- Challenge controls:
- Information not available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- not specified
- Concentration:
- no information available
- No. of animals per dose:
- no information available
- Details on study design:
- no information available
- Positive control substance(s):
- not specified
- Statistics:
- no information available
Results and discussion
- Positive control results:
- Information not available
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- Information not available
- Clinical observations:
- Macroscopic and histological evaluation of skin reaction was scored up to 48 hours after removal of the occlusive capsule. Under these experimental conditions, chlorodifluoromethane did not produce any cutaneous sensitising reaction.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: Information not available. Clinical observations: Macroscopic and histological evaluation of skin reaction was scored up to 48 hours after removal of the occlusive capsule. Under these experimental conditions, chlorodifluoromethane did not produce any cutaneous sensitising reaction..
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: none
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Macroscopic and histological evaluation of skin reaction was scored up to 48 hours after removal of the occlusive capsule. Under these experimental conditions, chlorodifluoromethane did not produce any cutaneous sensitising reaction.
- Executive summary:
Macroscopic and histological evaluation of skin reaction was scored up to 48 hours after removal of the occlusive capsule. Under these experimental conditions, chlorodifluoromethane did not produce any cutaneous sensitising reaction.
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