Registration Dossier
Registration Dossier
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EC number: 248-666-3 | CAS number: 27813-02-1
Endpoint summary
Administrative data
Description of key information
Additional information
The substance (methacrylic acid, monoester with propane-1,2-diol) has a log Pow value that is less than 3 (log Pow = 0.97), has a low potential for adsorption or binding to organic matter (no dissociable group; estimated Koc of 33.5) and is readily biodegradable. The distribution modeling (Mackay level III fugacity modeling) indicates that when methacrylic acid, monoester with propane-1,2-diol is released to air, water and soil in equal amounts, the substance will partition to soil and water predominantly, and to air to some small degree. Methacrylic acid, monoester with propane-1,2-diol will not partition to sediment following release to the water compartment. If released to soil, most of the substance will remain in soil with a portion transported to water. In both the aquatic and soil compartments it is anticipated that methacrylic acid, monoester with propane-1,2-diol will biodegrade rapidly and thus persistence in the aquatic and soil compartments is not anticipated. The predicted no effect concentration (PNEC) for soil was derived from the PNEC for freshwater using the equilibrium partitioning method. Using the PNECsoil value that was calculated using the equilibrium partitioning method, the risk characterization shows that the PEC/PNECsoil ratio for the terrestrial environment is <1, indicating testing of effects on terrestrial organisms can be waived for methacrylic acid, monoester with propane-1,2-diol.
Assessing the toxicity of methacrylic acid, monoester with propane-1,2-diol to birds is not necessary since a large mammalian data set is available. This data set documents the effects of the substance on terrestrial vertebrates. In addition, methacrylic acid, monoester with propane-1,2-diol is readily biodegradable and has a very low potential for bioaccumulation (log Pow = 0.97); therefore, secondary poisoning is not considered a relevant route of exposure for birds. If necessary, the available mammalian data can be used in place of bird toxicity studies to develop a PNECoral for secondary poisoning. Thus, toxicity to birds is waived for methacrylic acid, monoester with propane-1,2-diol.
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