Registration Dossier

Administrative data

Description of key information

One GLP study was available for acute oral and acute dermal toxicity, respectively. In both acute studies the LD50 was > 2000 mg/kg bw. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
2 000 mg/kg bw

Additional information

The harmonized data infers that 4,4 -methylenebis(2 -chloroaniline) is classified for R22, however latest studies performed by Japanese laboratories have shown that this classification is not justified.

Justification for classification or non-classification

Based on the results of the acute toxicity studies, the substance does not need to be classified according to the Dangerous Substance Directive 67/548/EC and CLP Regulation (EC) 1272/2008.

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