Registration Dossier
Registration Dossier
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EC number: 628-856-6 | CAS number: 1218787-29-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
GPMT study on coconitrile performed under GLP and according to OECD guideline 406 resulted to a weak reaction in only 10% of the animals. Accordingly, no classification is required for dermal sensitisation.
Migrated from Short description of key information:
Not Sensitising
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
GPMT study on coconitrile performed under GLP and according to OECD guideline 406 resulted to a weak reaction in only 10% of the animals. Accordingly, no classification is required for dermal sensitisation.
As chemical respiratory sensitisers also elicit positive results in predictive tests for contact sensitisation, the negative outcome for dermal sensitisation is also predictive for non respiratory sensitisation of the substance.
Migrated from Short description of key information:
Not Sensitising
Justification for classification or non-classification
GPMT study on coconitrile performed under GLP and according to OECD guideline 406 resulted to a weak reaction in only 10% of the animals. Accordingly, no classification is required for dermal sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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