Registration Dossier
Registration Dossier
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EC number: 628-856-6 | CAS number: 1218787-29-1
Endpoint summary
Administrative data
Description of key information
Acute toxicity: Oral LD50 > 5,000 mg/kg for rat (LD50 limit test - no mortality)
Key value for chemical safety assessment
Additional information
Coconitrile has shown to be of low acute toxicity following oral administration up to 5000 mg/kg. There were clinical signs observed after dosing that included pilo-erection, hunched posture, waddling, salivation, palor of the extremities, and diarrhea. All signs were completely cleared by day 5. There were no effects on body weight gains and no abnormal autopsy findings at necropsy.
Also comparable other nitriles as Tallownitrile and Oleylnitrile showed no mortality up to highest tested dose of 5000 mg/kg body weight.
Justification for classification or non-classification
Only limited toxicity was observed after oral dosing of 5000 mg/kg, and hence no classification for acute oral toxicity is indicated.
Based on the very low water solubility and relative high Pow of 5, the rate of transfer to epidermis is probably limited. However, the molecular size is not large and high Pow favours uptake in stratum corneum. As worst case, 100% dermal absorption is assumed although in view of anticipated slow uptake into epidermis, systemic peak concentrations will be lower following acute exposures compared to the oral route.
Coconitrile is further mildly irritating to skin, and not irritating to the eyes and consequently it is not expected to exert serious toxicity by dermal or inhalatory routes even when uptake is to be considered similar as following oral route.
Physical-chemical properties of coconitrile, being a liquid at room temperature with a relatively low vapour pressure (1.8 Pa at 20°C) and water solubility (ca. 25 mg/L), would also limit the likelihood of significant exposures by inhalation.
Consequently, Coconitrile need not be classified for acute toxicity by dermal or respiratory route.
Alkylnitriles do not contain aliphatic, alicyclic and aromatic hydrocarbons. Also lack of surface activity (based on structure) indicates there is no aspiration hazard for Coconitrile.
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