Registration Dossier
Registration Dossier
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EC number: 258-207-9 | CAS number: 52829-07-9
Neurotoxicity
Administrative data
Description of key information
The test substance was shown to act as an antagonist at the nicotinic acetylcholine receptors in in vitro studies or when administered parenterally. However, no adverse effects in terms of neurotoxicity could be observed when given orally in repeated dose toxicity studies, indicating a rather poor uptake and limited bioavailability and/or fast metabolic transformation in less active metabolites. In addition, in a recent OECD 443 study investigating developmental neurotoxicity no adverse findings were reported up to the highest dose level applied.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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