Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS 1,2-DICHLOROPROPANE
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP PUBLICATIONS
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name: 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Duration of treatment / exposure:
- 4h
- Number of animals:
- 3 rabbits (2male, 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Time point:
- other: 4 h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- > 1 - < 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within:
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: reversible after 8 days in 2/3 animals
Any other information on results incl. tables
Individual reactions at 24 hr:
Redness 2, 2, 2
Oedema 1, 1, 1
Individual reactions at 48 hr:
Redness 2, 1, 1
Oedema 0, 0, 0
Individual reactions at 72 hr:
Redness 1, 1, 1
Oedema 0, 0, 0
Individual reactions at 8 d
Redness 1, 0, 0
Oedema 0, 0, 0
Flaking skin at application site in all animals
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Slightly irritating to skin.
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