Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS 1,2-DICHLOROPROPANE
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP PUBLICATIONS
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method not available
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name: 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of exposure:
- 4 h
- Concentrations:
- Six male or female Sherman rats (approx. 100 - 150 g) were exposed to PDC vapor (nominal concentrations up to 2000 ppm) for 4 hr or 8 hr, then observed for a 14 day follow-up period.
- No. of animals per sex per dose:
- Sex: male/female
No. of Animals: 6
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2 000 ppm
- Exp. duration:
- 4 h
Any other information on results incl. tables
Results from a preliminary study, summarised in tabular form, indicate that there was 33-67% mortality following 4 hr exposure to 2000 ppm PDC (equivalent to 9.4 mg/l). There were 3/6 deaths in the definitive study following an 8 hr exposure to this same concentration. Thus the same extent of mortality was observed in rats exposed to PDC vapor for 4 hr or 8 hr. Since the longer exposure was not more hazardous than the shorter expsoure, it is concluded that these results most likely reflect the 4 hr acute toxicity of 1,2-dichloropropane in the rat.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4 hr inhalation LC50 for PDC in the rat is 2000 ppm (9.4 mg/l).
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