Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-421-2 | CAS number: 1843-05-6
Endpoint summary
Administrative data
Description of key information
The substance caused temporary mild transient reactions in rabbit eyes and no irritating reactions on rabbit skin. Both studies followed the procedure outline in OECD testing guideline 405 and 404 with minor deviations. Findings in eyes are sufficiently mild that no hazard classification is needed.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The studies for skin and eye irritation of the test substance were performed under the principles of GLP. Their design is comparable to that of the respective OECD testing guidelines with some deviations. These include determination of the body weight at the end of the study, the shorter observation period and testing of both intact and abraded skin. Since all findings healed within the short observation period, the deviations are considered acceptable. The test item is only described by code, information on purity is not available in the report. Overall, sufficient information is given to assign these studies the status of key studies. Draize scores were 0 for erythema and edema in the skin irriation study. In the eye irritation study, one of three animals showed mild iritis, which healed within 48h. All three animals showed mild effects on conjunctivae below the threshold of significance which healed within 72h.
The studies for skin and eye irritation of the dodecyloxy analogue were performed prior to the introduction of OECD testing guidelines and GLP. As such, they have some limitations in reporting details referring to the test item and the housing conditions. The observation period is limited to 72h post treatment. In this case, it is acceptable since no indication of an irritating effect was observed. The test item is only described by a company code; information on purity is not available in the report.
No experimental data is available regarding respiratory irritation.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008 (CLP). As a result the substance is not considered to be classified for skin irritation and for eye irritation under Regulation (EC) No 1272/2008, as amended for the eighth time in Regulation (EU) No 2016/218.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
