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EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions: Incomplete documentation, TA 102 or E.coli WP2 were not tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Principles of method if other than guideline:
- Method: other: Ames BN et al. (1975). Mutat. Res. 31, 347-364
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Cyclododecatrien 1,5,9
- IUPAC Name:
- Cyclododecatrien 1,5,9
- Details on test material:
- Cyclododecatrien 1,5,9 of Hüls AG, ID no. 426/870826, purity not reported
Constituent 1
Method
- Target gene:
- mutated gene loci responsible for histidine auxotrophy
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
- Additional strain / cell type characteristics:
- other: histidine auxotroph
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat S9 liver homogenate, male Bor: W/SW (SPF/TNO) rats; enzyme activity tested with aminoanthracene
- Test concentrations with justification for top dose:
- 10 to 5000 µg/plate
- Vehicle / solvent:
- dimethyl sulfoxide (DMSO) (CAS No. 67-68-5)
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- other: not reported but assumed that the vehicle dimethylsulfoxide served as control
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- see below
- Positive control substance:
- other: 2.5 µg nitrofluorene/plate: TA 98, TA 1538 (pos.) 2.5 µg sodium azide/plate: TA 100, TA 1535 (pos.) 50 µg aminoacridine/plate: TA 1537 (pos.)
- Remarks:
- enzyme activity of liver homogenate confirmed with aminoanthracene
- Details on test system and experimental conditions:
- Ames test
SYSTEM OF TESTING
- Metabolic activation system: Aroclor induced rat S9 liver homogenate, male Bor: W/SW (SPF/TNO) rats, enzyme activity confirmed with
aminoanthracene
ADMINISTRATION:
- Solvent: dimethyl sulfoxide (CAS No. 67-68-5)
- Positive and negative control groups and treatment:
2.5 µg nitrofluorene/plate: TA 98, TA 1538 (pos.)
2.5 µg sodium azide/plate: TA 100, TA 1535 (pos.)
50 µg aminoacridine/plate: TA 1537 (pos.)
negative: untreated plus solvent (not reported but assumed)
- Number of replicates: 2
- Pre-incubation: with and without metabolic activation - Evaluation criteria:
- Mutagenic effects (i.e ratio of revertant rates treated/control >= 2) at <= 5000 µg/plate with generally positive dose-response relationship in any strain
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: not reported; probably not observed
- Additional information on results:
- no further information
- Remarks on result:
- other: other: Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
no further information
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The test substance cyclododecatriene 1,5,9 proved to be non-mutagenic under the conditions of this study, both in the presence and in the absence of Aroclor-induced liver microsomes for all the test strains even in addition of 5,000 µg of test substance per plate and when the pre-incubation test was used. - Executive summary:
The test substance cyclododecatriene 1,5,9 proved to be non-mutagenic under the conditions of this study, both in the presence and in the absence of Aroclor-induced liver microsomes for all the test strains even in addition of 5,000 µg of test substance per plate and when the pre-incubation test was used.
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