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Diss Factsheets
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EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: no analytical verification of nominal concentrations
Data source
Reference
- Reference Type:
- publication
- Title:
- Robust summary for 1,5,9-cyclododecatriene (revised).
- Author:
- DuPont Safety, Health & Environmental Excellence Center, Wilmington (Del., USA)
- Year:
- 2 003
- Bibliographic source:
- U.S. EPA, 46 pp
Materials and methods
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclododeca-1,5,9-triene
- EC Number:
- 225-533-8
- EC Name:
- Cyclododeca-1,5,9-triene
- Cas Number:
- 4904-61-4
- Molecular formula:
- C12H18
- IUPAC Name:
- cyclododeca-1,5,9-triene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,5,9-cyclododecatriene, purity 100 %
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- STOCK AND TEST SOLUTION AND THEIR PREPARATION
- Vehicle, solvent: acetone, 2.5 ml/l
Test organisms
- Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- - fish were not fed during the test
Study design
- Test type:
- static
- Water media type:
- brackish water
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 22 +/- 1 degree C
- Dissolved oxygen:
- > 60% saturation for first 48 hours; > 40% saturation thereafter
- Nominal and measured concentrations:
- - Nominal concentrations: 0.3125; 0.625; 1.25; 2.5; 5.0 mg/l
- Additionally: 10; 50 mg/l test substance; 5.0; 25 ml/l vehicle control - Details on test conditions:
- TEST SYSTEM
- Number of replicates, fish per replicate: 2 replicates with 10 fish each
TEST CONDITIONS
- Intensity of irradiation: daylight 8-100 fc
- Photoperiod: approximately 16 hours daylight / 8 h darkness
TEST PARAMETER
- observations for biological response at 24-h intervals
STATISTICAL ANALYSIS
- LC50 values were determinded using probit analysis - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.02 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 1.69-2.42 mg/L
- Details on results:
- All deaths occurred within 24 hours.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
- Effect data (Mortality):
control, solvent control, 0.3125 mg/l, 0.625 mg/l: 0/20
1.25 mg/l: 2/20
2.5 mg/l: 14/20
5.0 mg/l: 20/20
Additional testing:
10.0 mg/l: all organisms dead within first hour
5.0 ml/l solvent control: 10 % mortality (between 24 and 48 hours)
30.0 mg/l: all organisms dead within 30 minutes
25 ml/l solvent control: all organisms dead within 40 min
- Other effects:
2.5 mg/l: Erratic swimming
5.0 mg/l: Twitching
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 was determined as 2.02 mg/L indicating that the test substance may be toxic to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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