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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
only male animals tested; lack of details on test substance
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Glycerides, mixed decanoyl and octanoyl
EC Number:
277-452-2
EC Name:
Glycerides, mixed decanoyl and octanoyl
Cas Number:
73398-61-5
IUPAC Name:
73398-61-5

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Remarks:
Gravimetric analyses were performed to determine the respirable test substance concentration.
Duration of exposure:
6 h
Concentrations:
28.1 µL/L air (calculated concentration)
measured respirable test substance concentration: 1.97 µL/ L air (< 5 and < 10 µm diameter particle size)
No. of animals per sex per dose:
10
Control animals:
other: yes, sham-exposed

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.97 other: µL/L air (analytical)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: max. attainable concentration
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.86 mg/L air (analytical)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: converted from µL/L by using a mean specific gravity value of 0.947
Mortality:
No mortality occured during the study period.
Clinical signs:
other: No clinical signs toxicity were observed in any of the animals during the 14-day observation period.
Body weight:
No effect on body weight was noted.
Gross pathology:
No abnormal findings.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU